机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100050, China.[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, 100050, China.[5]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, 100050, China.
Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke and H-type hypertension, which is defined as hypertension with hyperhomocysteinemia, is associated with cardio-cerebrovascular diseases. However, the impact of H-type hypertension on ECAS is mostly unknown. We designed this study to investigate the association between H-type hypertension and prevalence of ECAS. We included 2330 participants in this study and classified them into four groups: the control group without hypertension or hyperhomocysteinemia, isolated hypertension group, isolated hyperhomocysteinemia group and H-type hypertension group. We measured the baseline plasma total homocysteine levels and assessed ECAS by carotid duplex sonography twice at baseline and during follow up. We used a Cox regression model to analyse the association between H-type hypertension and ECAS. At baseline, 608 subjects suffered from H-type hypertension. Within two years of follow-up, asymptomatic ECAS occurred in 250 (10.73%) participants. After adjusting for relevant risk factors, we found H-type hypertension to be an independent risk factor for asymptomatic ECAS (relative risk (RR) 3.16, 95% confidence interval (95% CI) 2.00-5.00). Our findings provide direct evidence for the importance of H-type hypertension in the occurrence of ECAS and as a potential therapeutic target for carotid atherosclerosis.
基金：
This work was supported by grant from Beijing Municipal
Administration of Hospitals’ Ascent Plan (code. DFL20150501) and Beijing Health System Medical High Level
Academic Leader Plan (No. 2014-2010, Xingquan Zhao)
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[2]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100050, China.[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, 100050, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[2]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100050, China.[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, 100050, China.
推荐引用方式(GB/T 7714)：
Zhang Jia,Liu Yanfang,Wang Anxin,et al.Association between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis[J].SCIENTIFIC REPORTS.2018,8(1):-.doi:10.1038/s41598-018-19740-0.
APA：
Zhang, Jia,Liu, Yanfang,Wang, Anxin,Wang, Dandan,Jiang, Ruixuan...&Zhao, Xingquan.(2018).Association between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis.SCIENTIFIC REPORTS,8,(1)
MLA：
Zhang, Jia,et al."Association between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis".SCIENTIFIC REPORTS 8..1(2018):-
