机构：[1]Beijing Neurosurgical Institute, Capital Medical University, 6 Tiantanxili, Beijing 100050, China研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantanxili, Beijing 100050, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China
MicroRNAs (miRNAs) may act as prognostic biomarkers in a variety of cancers. The aim of this study was to identify and evaluate a prognostic miRNA signature in patients with lower-grade gliomas (LGGs). miRNA expression profiles and clinical data of patients with LGGs from the Chinese Glioma Genome Atlas (CGGA; the training cohort) and The Cancer Genome Atlas (TCGA; the validation cohort) were analyzed, and the least absolute shrinkage and selection operator Cox regression model was used to identify the miRNA signature, which was combined with clinical prognostic factors to develop an individualized survival prediction model. Gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were conducted to reveal the biological implications of the signature. We identified a four-miRNA signature that stratified patients in the training cohort into low- or high-risk groups according to overall survival time, a finding that was verified in the validation cohort. Multivariate Cox regression analysis indicated that the four-miRNA signature was an independent prognostic biomarker, and a nomogram combining this miRNA signature with clinicopathological and molecular factors showed high prognostic accuracy for individualized survival prediction in both TCGA (C-index = 0.83) and CGGA (C-index = 0.68) cohorts. Functional annotation indicated that the major biological processes of this prognostic miRNA signature were enriched in cell cycle and DNA repair-associated biological processes. Our findings indicated that our newly discovered four-miRNA signature may be an effective independent prognostic factor for the prediction of patients with LGGs.
基金：
Beijing Postdoctoral Research FoundationChina Postdoctoral Science Foundation [2016ZZ-37]
第一作者机构：[1]Beijing Neurosurgical Institute, Capital Medical University, 6 Tiantanxili, Beijing 100050, China[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantanxili, Beijing 100050, China
通讯作者：
通讯机构：[1]Beijing Neurosurgical Institute, Capital Medical University, 6 Tiantanxili, Beijing 100050, China[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantanxili, Beijing 100050, China[3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Zenghui Qian,Yiming Li,Xing Fan,et al.Prognostic value of a microRNA signature as a novel biomarker in patients with lower-grade gliomas[J].JOURNAL OF NEURO-ONCOLOGY.2018,137(1):127-137.doi:10.1007/s11060-017-2704-5.
APA：
Zenghui Qian,Yiming Li,Xing Fan,Chuanbao Zhang,Yinyan Wang...&Xing Liu.(2018).Prognostic value of a microRNA signature as a novel biomarker in patients with lower-grade gliomas.JOURNAL OF NEURO-ONCOLOGY,137,(1)
MLA：
Zenghui Qian,et al."Prognostic value of a microRNA signature as a novel biomarker in patients with lower-grade gliomas".JOURNAL OF NEURO-ONCOLOGY 137..1(2018):127-137
