机构：[1]Department of Otolaryngology-Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing 100045,China临床科室耳鼻咽喉头颈外科首都医科大学附属北京儿童医院[2]Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck Surgery, Beijing Pediatric Research Institute,Capital Medical University, Beijing 100020, China临床科室科研平台耳鼻咽喉头颈外科儿科研究所首都医科大学附属北京儿童医院
Background: The safety and efficacy of sublingual immunotherapy (SLIT) have been confirmed by many studies. However, in China, the research on efficacy and safety in young and older children with allergic rhinitis (AR) is still rare. Objective: The aim of this retrospective study is to evaluate the efficacy and safety of SLIT with Dermatophagoides farinae drops in pre-school and school-age children with AR. Methods: A total of 282 subjects aged 2-13 years with AR received a two-year course of sublingual immunotherapy along with pharmacotherapy. According to the age, patients were defined as the pre-school group (2-6 years old, n=116) and school-age group (7-13 years old, n=166). Total nasal rhinitis symptom scores (TNSS), visual analogue score (VAS) and total medication scores (TMS) were evaluated at four time points: baseline, after SLIT for half a year, one year and two years. The adverse events (AEs) were evaluated at each visit. Results: After two-year SLIT, the four rhinitis symptom scores, TNSS, VAS and TMS scores were significantly lower than baseline (all P<0.05). The comparison of efficacy between one and two-year duration showed no significant difference in global clinical outcomes (all P>0.05). In addition, there were no significant differences between the pre-school and school-age group in TNSS (all P>0.05), VAS (all P>0.05) and TMS scores (P>0.05) after SLIT for half a year, one year and two years. No severe systemic AEs were reported. Conclusion: SLIT with D. farinae drops is clinically effective and safe in pre-school and school age patients with house dust mites (HDMs)-induced AR. (C) 2018 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
基金：
Beijing Municipal Science and Technology Project [Z131100006813044]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201508]
第一作者机构：[1]Department of Otolaryngology-Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing 100045,China
通讯作者：
通讯机构：[1]Department of Otolaryngology-Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing 100045,China[2]Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck Surgery, Beijing Pediatric Research Institute,Capital Medical University, Beijing 100020, China
推荐引用方式(GB/T 7714)：
Tang L. -X.,Yang X. -J.,Wang P. -P.,et al.Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae drops in pre-school and school-age children with allergic rhinitis[J].ALLERGOLOGIA ET IMMUNOPATHOLOGIA.2018,46(2):107-111.doi:10.1016/j.aller.2017.09.022.
APA：
Tang, L. -X.,Yang, X. -J.,Wang, P. -P.,Ge, W. -T.,Zhang, J....&Ni, X..(2018).Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae drops in pre-school and school-age children with allergic rhinitis.ALLERGOLOGIA ET IMMUNOPATHOLOGIA,46,(2)
MLA：
Tang, L. -X.,et al."Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae drops in pre-school and school-age children with allergic rhinitis".ALLERGOLOGIA ET IMMUNOPATHOLOGIA 46..2(2018):107-111
