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Evaluation of a new fluorescent reagent, fluorescent brightener 85, for the diagnosis of suspected onychomycosis compared with potassium hydroxide

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机构: [1]Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China [2]Department of Dermatology & Venereology, Peking University First Hospital and Research Center for Medical Mycology, Peking University, Beijing, China [3]Department of Clinical Laboratory, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
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关键词: 10% KOH method direct microscopy fluorescent brightener 85 fluorescent method onychomycosis

摘要:
Onychomycosis is a common fungal infection in dermatology clinics. The commonly used diagnostic method, potassium hydroxide (KOH) direct microscopy, does not have a high-positive detection rate. Therefore, a new diagnostic method is needed to confirm onychomycosis. The objective of this research was to use fluorescent brightener 85 (FB 85), a new fluorescent reagent for fungi detection, and to evaluate this new method based on the diagnostic positive rate, accuracy and efficiency in suspected onychomycosis compared with the KOH method. Subungual debris was collected from clinically suspected onychomycosis cases and divided into two parts. The parts were examined by FB 85 and 10% KOH solution, respectively. In total, 108 patients with suspected onychomycosis were recruited. The positive rates of FB 85 and KOH were 88.9% and 55.6%, respectively. The patients showed significant statistical differences (P<.001). Compared with the KOH method, the FB 85 fluorescent method was an accurate and efficient method with a higher positive rate. This method could increase the diagnostic accuracy and efficiency of onychomycosis detection.

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出版当年[2017]版:
大类 | 3 区 医学
小类 | 3 区 皮肤病学 3 区 真菌学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 皮肤病学 2 区 真菌学
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出版当年[2016]版:
Q2 DERMATOLOGY Q2 MYCOLOGY
最新[2023]版:
Q1 DERMATOLOGY Q2 MYCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China [*2]Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
通讯作者:
通讯机构: [1]Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China [3]Department of Clinical Laboratory, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China [*1]Department of Clinical Laboratory, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China [*2]Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
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