机构：[a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心首都医科大学附属天坛医院[b]China National Clinical Research Center for Neurological Diseases, Beijing, China[c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China[e]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China[f]Department of Neurology, Tangshan Gongren Hospital, North China University of Science and Technology, Tangshan, China[g]Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Beijing Institute of Heart Long and Blood Vessel Diseases, Capital Medical University, Beijing, China临床科室心脏外科中心血管科首都医科大学附属安贞医院
Background and aims: Oxidized low-density lipoprotein (oxLDL) has a defined role in the genesis and development of atherosclerosis, however, whether it is related to severity of neurological deficits is rarely reported. The aim of our study was to investigate the potential association between oxLDL and the National Institutes of Health Stroke Scale (NIHSS) score among patients with acute ischemic stroke. Methods: Between January 2014 and October 2014, we recruited 4111 patients with acute ischemic stroke (AIS), who were admitted within 7 days-43 hospitals in China, and participated in the SOS-Stroke Study. We collected detailed clinical data and then tested the relationship between oxLDL and the NIHSS score using a multivariate linear regression analysis. Results: After adjusting for age, gender, ethnicity, marriage and other confounding variables, the elevated NIHSS score was significantly associated with increased oxLDL levels, and each 1-mg/dL elevation in oxLDL concentration resulted in an increase of 0.027 in the NIHSS score. Conclusions: A positive correlation was found between plasma levels of oxLDL and the NIHSS score in patients with acute ischemic stroke. Higher plasma levels of oxLDL potentially suggest a worse prognosis in AIS patients. (c) 2018 Elsevier B.V. All rights reserved.
基金：
China Stroke Prevention Project of the National Health and Family Planning Commission; National natural science foundation of ChinaNational Natural Science Foundation of China [81600999, 81673247]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区外周血管病3 区心脏和心血管系统
最新[2023]版：
大类|2 区医学
小类|2 区外周血管病3 区心脏和心血管系统
JCR分区：
出版当年[2016]版：
Q1PERIPHERAL VASCULAR DISEASEQ2CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构：[a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[b]China National Clinical Research Center for Neurological Diseases, Beijing, China[c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China[e]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[b]China National Clinical Research Center for Neurological Diseases, Beijing, China[c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China[*1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing, 100050, China.
推荐引用方式(GB/T 7714)：
Anxin Wang,Ying Cui,Xia Meng,et al.The relationship between oxidized low-density lipoprotein and the NIHSS score among patients with acute ischemic stroke: The SOS-Stroke Study[J].ATHEROSCLEROSIS.2018,270:21-25.doi:10.1016/j.atherosclerosis.2018.01.028.
APA：
Anxin Wang,Ying Cui,Xia Meng,Zhaoping Su,Yibin Cao...&Yilong Wang.(2018).The relationship between oxidized low-density lipoprotein and the NIHSS score among patients with acute ischemic stroke: The SOS-Stroke Study.ATHEROSCLEROSIS,270,
MLA：
Anxin Wang,et al."The relationship between oxidized low-density lipoprotein and the NIHSS score among patients with acute ischemic stroke: The SOS-Stroke Study".ATHEROSCLEROSIS 270.(2018):21-25
