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PXR as a mediator of herb-drug interaction

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收录情况： ◇ SCIE

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机构： [a]Pharmaceutical Sciences Graduate Program, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA [b]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [c]Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA [d]Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA

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关键词： Drug metabolism Herb-drug interaction PXR St John's Wort Xenobiotics

摘要：

Medicinal herbs have been a part of human medicine for thousands of years. The herb -drug interaction is an extension of drug-drug interaction, in which the consumptions of herbs cause alterations in the metabolism of drugs the patients happen to take at the same time. The pregnane X receptor (PXR) has been established as one of the most important transcriptional factors that regulate the expression of phase I enzymes, phase II enzymes, and drug transporters in the xenobiotic responses. Since its initial discovery, PXR has been implicated in multiple herb-drug interactions that can lead to alterations of the drug's pharmacokinetic properties and cause fluctuating therapeutic efficacies, possibly leading to complications. Regions of the world that heavily incorporate herbalism into their primary health care and people turning to alternative medicines as a personal choice could be at risk for adverse reactions or unintended results from these interactions. This article is intended to highlight our understanding of the PXR-mediated herb-drug interactions. Copyright (C) 2017, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 3 区食品科技 4 区药学

最新[2023]版：

大类 | 3 区农林科学

小类 | 4 区食品科技 4 区药学

JCR分区：

出版当年[2016]版：

Q1 FOOD SCIENCE & TECHNOLOGY Q2 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q2 FOOD SCIENCE & TECHNOLOGY Q2 PHARMACOLOGY & PHARMACY

影响因子： 2.6 最新[2023版] 4.9 最新五年平均 3.048 出版当年[2016版] 1.685 出版当年五年平均 1.98 出版前一年[2015版] 2.852 出版后一年[2017版]

第一作者：

第一作者机构： [a]Pharmaceutical Sciences Graduate Program, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA

通讯作者：

通讯机构： [a]Pharmaceutical Sciences Graduate Program, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA [c]Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA [d]Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA [*1]Center for Pharmacogenetics, 306 Salk Pavilion, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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