机构：[a]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, P.R. China[b]Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China诊疗科室消化内科首都医科大学附属天坛医院[c]Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China
Background: Biomarkers for esophageal squamous cell carcinoma (ESCC) identification with high sensitivity are not well established. Since abnormal expression of cadherins has been widely reported in cancer, we explored its feasibility as an ESCC biomarker. Methods: Expression of E-cadherin and N-cadherin were detected in 150 esophageal tissues by immunohistochemistry. Staining strength and percentage in different subcellular structures of each specimen were evaluated by 2 independent pathologists. A logistic regression-based classifier derived from E-cadherin and N-cadherin staining was generated. Results: E-cadherin exhibited decreased membrane expression in ESCC, while N-cadherin exhibited decreased expression in the nucleus but elevated expression in the cytoplasm. Both E-cadherin and N-cadherin could distinguish ESCC tissues from non-cancerous tissues (area under the curve (AUC) = 0.748, 0.801, respectively). E-cadherin and N-cadherin staining scores could be merged into a cadherin (CDH) logistic index, which showed better discrimination (AUC = 0.909) than E-cadherin or N-cadherin alone. Further investigation indicated that the CDH logistic index was significantly correlated with tumor size and differentiation in ESCC. Conclusion: Both E-cadherin and N-cadherin had a strong expression shift in ESCC compared with non-cancerous tissues. The CDH logistic index, a parameter integrating the expression data of both cadherins, could be used as a marker with high sensitivity and specificity in the identification of ESCC. (c) 2018 S. Karger GmbH, Freiburg
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81302160, 81272447]; Beijing Natural Science FoundationBeijing Natural Science Foundation; Beijing Municipal Commission of EducationBeijing Municipal Commission of Education [KZ201410025024]
第一作者机构：[a]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, P.R. China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, P.R. China[c]Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China[*1]Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, P. R. China[*2]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical Universitym Beijing, 100050, P.R. China
推荐引用方式(GB/T 7714)：
Shengtao Zhu,Juan Liu,Li Min,et al.Cadherin Expression Shift Could Well Distinguish Esophageal Squamous Cell Carcinoma from Non-Cancerous Esophageal Tissues[J].ONCOLOGY RESEARCH AND TREATMENT.2018,41(6):380-385.doi:10.1159/000487267.
APA：
Shengtao Zhu,Juan Liu,Li Min,Xiujing Sun,Qingdong Guo...&Shutian Zhang.(2018).Cadherin Expression Shift Could Well Distinguish Esophageal Squamous Cell Carcinoma from Non-Cancerous Esophageal Tissues.ONCOLOGY RESEARCH AND TREATMENT,41,(6)
MLA：
Shengtao Zhu,et al."Cadherin Expression Shift Could Well Distinguish Esophageal Squamous Cell Carcinoma from Non-Cancerous Esophageal Tissues".ONCOLOGY RESEARCH AND TREATMENT 41..6(2018):380-385
