机构：[1]Stereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China,研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Beijing Key Laboratory of Neurostimulation, Beijing, China,[3]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[4]Department of Pathology, Peking University First Hospital Fengtai Hospital, Beijing, China,[5]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[6]Department of Epilepsy Center, Peking University First Hospital Fengtai Hospital, Beijing, China,[7]Department of Neuroimage, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,首都医科大学附属天坛医院[8]Department of Neurosurgery, Hainan General Hospital, Haikou, China
Purpose: To determine the diagnostic value of individual image post-processing techniques in a series of patients who underwent extratemporal operations for histologically proven, MRI-negative focal cortical dysplasia (FCD). Methods: The morphometric analysis program (MAP), PET/MRI co-registration and statistical parametric mapping (SPM) analysis of PET (SPM-PET) techniques were analyzed in 33 consecutive patients. The epileptogenic zone (EZ) assumed by MAP, PET/MRI, and SPM-PET was compared with the location of the FCD lesions determined by stereoelectroencephalography (SEEG) and histopathological study. The detection rate of each modality was statistically compared. Results: Three lesions were simultaneously detected by the three post-processing methods, while two lesions were only MAP positive, and 8 were only PET/MRI positive. The detection rate of MAP, PET/MRI, SPM-PET and the combination of the three modalities was 24.2, 90.9, 57.6, and 97.0%, respectively. Taking the pathological subtype into account, no type I lesions were detected by MAP, and PET/MRI was the most sensitive method for detecting FCD types II and IIA. During a mean follow-up period of 22.94 months, seizure freedom was attained in 26/33 patients (78.8%) after focal corticectomy. Conclusions: MAP, PET/MRI, and SPM-PET provide complementary information for FCD detection, intracranial electrode design, and lesion resection. PET/MRI was particularly useful, with the highest detection rate of extratemporal MRI-negative FCD.
基金：
capital (China) health research and development of special fund [2016-1-1071]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z161100000216130]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81471327]; Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20150503]; Application Technology Research and Development and Special Demonstration Projects of Hainan Province [ZDXM2015068]
第一作者机构：[1]Stereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Neurostimulation, Beijing, China,
通讯作者：
通讯机构：[1]Stereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Neurostimulation, Beijing, China,[3]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,
推荐引用方式(GB/T 7714)：
Hu Wen-han,Wang Xiu,Liu Li-na,et al.Multimodality Image Post-processing in Detection of Extratemporal MRI-Negative Cortical Dysplasia[J].FRONTIERS IN NEUROLOGY.2018,9(JUN):-.doi:10.3389/fneur2018.00450.
APA：
Hu, Wen-han,Wang, Xiu,Liu, Li-na,Shao, Xiao-qiu,Zhang, Kai...&Zhang, Jian-guo.(2018).Multimodality Image Post-processing in Detection of Extratemporal MRI-Negative Cortical Dysplasia.FRONTIERS IN NEUROLOGY,9,(JUN)
MLA：
Hu, Wen-han,et al."Multimodality Image Post-processing in Detection of Extratemporal MRI-Negative Cortical Dysplasia".FRONTIERS IN NEUROLOGY 9..JUN(2018):-
