机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[2]Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China,[3]China National Clinical Research Center for Neurological Diseases, Beijing, China,[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,[5]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China,[6]Trinity College of Arts and Sciences, Duke University, Durham, NC, USA
Although there is no consensus on the exact definition of precision medicine, it is generally agreed upon that the term entails diagnosis and therapy tailored to the individual patient. Precision medicine has seen major advances in the past two decades, many of which are relevant to ischemic stroke or transient ischemic attack (TIA). Advances include substantial improvements in high-throughput technologies, collaborations between the fields of biology and medicine, increasingly advanced biomedical informatics, the development of multimodal brain imaging techniques, as well as the widespread usage of electronic medical records and big data. Precision medicine in ischemic stroke or TIA is still in its infancy, but there have already been changes in clinical care from a one-size-fits-all model to a more precise, individualized approach. However, further studies are urgently needed to bridge the gaps between clinical studies and precision clinical practice. We discuss here the advances and challenges for precision medicine in ischemic stroke or TIA at its current stage, focusing on genetic predispositions, pharmacogenetics, omics, brain imaging and big data.
基金：
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2006BA101A11, 2008ZX09312-008, 2011BAI08B01, 2011BAI08B02, 2012ZX09303, 2013BAI09B14, 2013BAI09B03, 2015BAI12B02, 2015BAI12B04]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [D15110700200000, D151100002015001, D151100002015002, Z161100000516223, Z141107002514125]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81322019]; China Postdoctoral Science Foundation GrantChina Postdoctoral Science Foundation [2014T70093]; Fujian Provincial Natural Science Foundation [2015J01394]; Beijing Biobank of Cerebral Vascular Disease [D131100005313003]
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China,[3]China National Clinical Research Center for Neurological Diseases, Beijing, China,[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[3]China National Clinical Research Center for Neurological Diseases, Beijing, China,[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,[5]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China,[*1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing, China, 100050,
推荐引用方式(GB/T 7714)：
Lin Yi,Li Zixiao,Liu Chelsea,et al.Towards precision medicine in ischemic stroke and transient ischemic attack[J].FRONTIERS IN BIOSCIENCE-LANDMARK.2018,23(7):1338-1359.doi:10.2741/4647.
APA：
Lin, Yi,Li, Zixiao,Liu, Chelsea&Wang, Yongjun.(2018).Towards precision medicine in ischemic stroke and transient ischemic attack.FRONTIERS IN BIOSCIENCE-LANDMARK,23,(7)
MLA：
Lin, Yi,et al."Towards precision medicine in ischemic stroke and transient ischemic attack".FRONTIERS IN BIOSCIENCE-LANDMARK 23..7(2018):1338-1359
