机构：[1]Neural Reconstruction Department, Beijing Neurosurgical Institute, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, China研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院
Medulloblastoma (MB) is a rare primary brain tumor in adults. We previously evaluated that combining both clinical and molecular classification could improve current risk stratification for adult MB. In this study, we aimed to identify the prognostic value of Ki-67 index in adult MB. Ki-67 index of 51 primary adult MBs was reassessed using a computer-based image analysis (Image-Pro Plus). All patients were followed up ranging from 12 months up to 15 years. Gene expression profiling and immunochemistry were used to establish the molecular subgroups in adult MB. Combined risk stratification models were designed based on clinical characteristics, molecular classification and Ki-67 index, and identified by multivariable Cox proportional hazards analysis. In our cohort, the mean Ki-67 value was 30.0 +/- 11.3% (range 6.56-63.55%). The average Ki-67 value was significantly higher in LC/AMB than in CMB and DNMB (P = .001). Among three molecular subgroups, Group 4-tumors had the highest average Ki-67 value compared with WNT- and SHH-tumors (P = .004). Patients with Ki-67 index large than 30% displayed poorer overall survival (OS) and progression free survival (PFS) than those with Ki-67 less than 30% (OS: P = .001; PFS: P = .006). Ki-67 index (i.e. > 30%, < 30%) was identified as an independent significant prognostic factor (OS: P = .017; PFS: P = .024) by using multivariate Cox proportional hazards model. In conclusion, Ki-67 index can be considered as a valuable independent prognostic biomarker for adult patients with MB.
基金：
Beijing Talents Fund [2016000021469G216]; Capital Health Research and Development of Special [2018-2-1073]
第一作者机构：[1]Neural Reconstruction Department, Beijing Neurosurgical Institute, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, China[2]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Neural Reconstruction Department, Beijing Neurosurgical Institute, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, China[2]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Fu Zhao,Jing Zhang,Peng Li,et al.Prognostic value of Ki-67 index in adult medulloblastoma after accounting for molecular subgroup: a retrospective clinical and molecular analysis[J].JOURNAL OF NEURO-ONCOLOGY.2018,139(2):333-340.doi:10.1007/s11060-018-2865-x.
APA：
Fu Zhao,Jing Zhang,Peng Li,Qiangyi Zhou,Shun Zhang...&Pinan Liu.(2018).Prognostic value of Ki-67 index in adult medulloblastoma after accounting for molecular subgroup: a retrospective clinical and molecular analysis.JOURNAL OF NEURO-ONCOLOGY,139,(2)
MLA：
Fu Zhao,et al."Prognostic value of Ki-67 index in adult medulloblastoma after accounting for molecular subgroup: a retrospective clinical and molecular analysis".JOURNAL OF NEURO-ONCOLOGY 139..2(2018):333-340
