Clinical characteristics and etiology of bacterial meningitis in Chinese children > 28 days of age, January 2014-December 2016: A multicenter retrospective study
机构：[a]Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China, Beijing, China职能科室临床流行病与循证医学中心首都医科大学附属北京儿童医院[b]Department of Infectious Diseases, Shenzhen Children’s Hospital, Shenzhen, China[c]Department of Infectious Diseases, Qilu Children’s Hospital of Shandong University, Jinan, China[d]Department of Neurology, Children’s Hospital of Nanjing Medical University, Nanjing, China[e]Department of Infectious Diseases, Kunming Children’s Hospital, Kunming Medical University, Kunming, China[f]Department of Pediatric, Affiliated Xingtai People’s Hospital of Hebei Medical University, Xingtai, China[g]Department of Pediatric Neurology, Jiangxi Provincial Children’s Hospital, Nanchang, China[h]Department of Infectious Diseases, Baoding Children’s Hospital, Hebei Medical University, Baoding, China[i]Department of No. 3 Pediatric Internal, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China[j]Department of Children’s Diseases, Daming County People’s Hospital, Handan, China[k]Pediatric Intensive Care Unit, Bao’an Maternity and Child Health Hospital, Shenzhen, China[l]Department of Pediatric, Liaocheng People’s Hospital, Liaocheng, China[m]BGI Genomics Co., Ltd., Shenzhen, China[n]Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China, Beijing, China医技科室科研平台职能科室呼吸疾病研究室临床流行病与循证医学中心临床研究中心儿科研究所首都医科大学附属北京儿童医院
Objective: To explore the clinical characteristics and etiology of bacterial meningitis (BM) in Chinese children. Method: BM cases in children 28 days to 18 years old were collected from January 2014-December 2016 and screened according to World Health Organization standards. Clinical features, pathogens, and resistance patterns were analyzed. Results: Overall, 837 cases were classified into five age groups: 28 days-2 months (17.0%), 3-11 months (27.8%), 12-35 months (24.0%), 3-6 years (13.9%), and >6 years (17.3%). Major pathogens were Streptococcus pneumoniae (S. pneumoniae, n = 136, 46.9%), group B Streptococcus (GBS, n = 29, 10.0%), and Escherichia coli (E. coli, n = 23, 7.9%). In infants < 3 months old, GBS (46.5%) and E. coli (23.3%) were most common; in children > 3 months old, S. pneumoniae (54.7%), which had a penicillin non-susceptibility rate of 55.4% (36/65), was most frequent. The resistance rates of S. pneumoniae and E. coli to cefotaxime and ceftriaxone were 14.0%/40.0% and 11.3%/68.4%, respectively. All GBS isolates were sensitive to penicillin. Conclusions: The occurrence of BM peaked in the first year of life, while S. pneumoniae was the predominant pathogen in children >3 months of old. The antibiotic resistance of S. pneumoniae was a concern. (c) 2018 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
基金：
This study was reviewed and approved by the Ethics Committee of Beijing Children’s Hospital Affiliated to Capital Medical University and the Medical Ethical Committees of the selected hospitals.
第一作者机构：[a]Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China, Beijing, China[b]Department of Infectious Diseases, Shenzhen Children’s Hospital, Shenzhen, China
共同第一作者：
通讯作者：
通讯机构：[a]Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China, Beijing, China[l]Department of Pediatric, Liaocheng People’s Hospital, Liaocheng, China
推荐引用方式(GB/T 7714)：
Chi Li,Wen-ya Feng,Ai-wei Lin,et al.Clinical characteristics and etiology of bacterial meningitis in Chinese children > 28 days of age, January 2014-December 2016: A multicenter retrospective study[J].INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES.2018,74:47-53.doi:10.1016/j.ijid.2018.06.023.
APA：
Chi Li,Wen-ya Feng,Ai-wei Lin,Guo Zheng,Yan-chun Wang...&Gang Liu.(2018).Clinical characteristics and etiology of bacterial meningitis in Chinese children > 28 days of age, January 2014-December 2016: A multicenter retrospective study.INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,74,
MLA：
Chi Li,et al."Clinical characteristics and etiology of bacterial meningitis in Chinese children > 28 days of age, January 2014-December 2016: A multicenter retrospective study".INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 74.(2018):47-53
医学