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Role of the CHADS(2) Score in the Evaluation of Carotid Atherosclerosis in Patients with Atrial Fibrillation Undergoing Carotid Artery Ultrasonography

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机构： [1]The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health and the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China [2]Department of Emergency, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [3]Department of Cardiology Group Two, Weihai MunicipalHospital, Weihai, Shandong, China [4]Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Objective. This study investigated the characteristics of carotid atherosclerosis in patients with atrial fibrillation (AF) and determined the feasibility and significance of the CHADS(2) score in predicting the degree of carotid atherosclerosis. Methods. Consecutive patients (n = 109) with nonvalvular AF were registered and classified into two groups, the paroxysmal AF group (n = 59) and persistent AF group (n = 50). Fifty healthy patients, matched by sex and age, were considered the control group. All patients were examined using carotid ultrasound and velocity vector imaging (VVI). Results. Compared with the control group, the mean intimalmedial thickness in the paroxysmal AF group (0.56 +/- 0.11 versus 0.61 +/- 0.10, respectively, P < 0.05) and the persistent AF group (0.56 +/- 0.11 versus 0.64 +/- 0.13, respectively, P < 0.001) was significantly increased. The plaque index (PI) in the persistent AF group was significantly higher than that observed in the paroxysmal AF group (1.05 1 1.33 versus 1.42 +/- 1.47, respectively, P < 0.001). Regarding the VVI indices, those reflecting the long-axis longitudinal motion function of carotid arteries were significantly decreased in both AF groups. Compared with the control group, a significantly lower total longitudinal displacement (tLoD) index was observed in the persistent AF group (0.73 +/- 0.66 versus 0.31 +/- 0.23, respectively, P < 0-0001) and the paroxysmal AF group (0.73 +/- 0.66 versus 0.34 +/- 0.17, P < 0.0001). The CHADS(2) score was related to indicators reflecting the structure and function of the carotid artery. Conclusions. Carotid arterial structure and function were significantly altered in patients with AF. The degree of carotid atherosclerosis depended on the duration of AF. The CHADS(2) score may be useful as a predictor of the extent of carotid atherosclerosis in patients with AF.

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出版当年[2017]版：

大类 | 3 区生物

小类 | 3 区生物工程与应用微生物 4 区医学：研究与实验

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无

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出版当年[2016]版：

Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.6 最新[2023版] 3.1 最新五年平均 2.476 出版当年[2016版] 2.587 出版当年五年平均 2.134 出版前一年[2015版] 2.583 出版后一年[2017版]

第一作者：

第一作者机构： [1]The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health and the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China [2]Department of Emergency, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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通讯作者：

通讯机构： [1]The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health and the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China

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