机构：[1]Department of Movement Disorders, Center for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.[3]Department of Hematology and Oncology, Jingxi Campus, Beijing ChaoYang Hospital, Capital Medical University, Beijing, China.[4]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.研究所北京市神经外科研究所首都医科大学附属天坛医院[5]Hebrew Seniorlife Institution for Aging Research, Harvard Medical School, Boston, Massachusetts, USA.
This study aims to investigate how the frequency settings of deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) influence the motor symptoms of Parkinson's disease (PD). Stimulation with frequencies less than 100 Hz (mostly 60 or 80 Hz) is considered low-frequency stimulation (LFS) and with frequencies greater than 100 Hz (mostly 130 or 150 Hz) is considered high-frequency stimulation (HFS). We conducted a comprehensive literature review and meta-analysis with a random-effect model. Ten studies with 132 patients were included in our analysis. The pooled results showed no significant difference in the total Unified Parkinson Disease Rating Scale part III (UPDRS-III) scores (mean effect, -1.50; p = 0.19) or the rigidity subscore between HFS and LFS. Compared to LFS, HFS induced greater reduction in the tremor subscore within the medication-off condition (mean effect, 1.01; p = 0.002), while no significance was shown within the medication-on condition (mean effect, 0.01; p = 0.92). LFS induced greater reduction in akinesia subscore (mean effect, -1.68, p = 0.003), the time to complete the stand-walk-sit (SWS) test (mean effect, -4.84; p < 0.00001), and the number of freezing of gait (FOG) (mean effect, -1.71; p = 0.03). These results suggest that two types of frequency settings may have different effects, that is, HFS induces better responses for tremor and LFS induces greater response for a kinesia, gait, and FOG, respectively, which are worthwhile to be confirmed in future study, and will ultimately inform the clinical practice in the management of PD using STN-DBS.
基金：
National Key Technology Research and Development Program of the Ministry of Science and Technology of The People's Republic of China [2016YFC1306501]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81571226, 81771367]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z17110700100000, Z151100003915117, Z151100003915150]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7164254]; Irma and Paul Milstein Program for Senior Health Fellowship Award from Milstein Medical Asian American Partnership (MMAAP) Foundation
第一作者机构：[1]Department of Movement Disorders, Center for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Movement Disorders, Center for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.
推荐引用方式(GB/T 7714)：
Su Dongning,Chen Huimin,Hu Wanli,et al.Frequency-dependent effects of subthalamic deep brain stimulation on motor symptoms in Parkinson's disease: a meta-analysis of controlled trials[J].SCIENTIFIC REPORTS.2018,8(1):-.doi:10.1038/s41598-018-32161-3.
APA：
Su, Dongning,Chen, Huimin,Hu, Wanli,Liu, Yuye,Wang, Zhan...&Feng, Tao.(2018).Frequency-dependent effects of subthalamic deep brain stimulation on motor symptoms in Parkinson's disease: a meta-analysis of controlled trials.SCIENTIFIC REPORTS,8,(1)
MLA：
Su, Dongning,et al."Frequency-dependent effects of subthalamic deep brain stimulation on motor symptoms in Parkinson's disease: a meta-analysis of controlled trials".SCIENTIFIC REPORTS 8..1(2018):-
