Prospective investigation of folic acid supplements before and during early pregnancy and paediatric and adult cancers in the Chinese children and families cohort: a pilot study in a sample of rural and urban families
机构：[1]Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA[2]National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China[3]National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA[4]Center for Global Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA[5]CDC Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA[6]Independent Consultant, Beijing, China[7]Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland, USA[8]National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China[9]Department of Surgery, Laoting County Maternal and Child Health Hospital, Laoting, China[10]Taicang County Maternal and Child Hospital, Taicang, China[11]Chinese Center for Disease Control and Prevention, Beijing, China[12]Center of Pediatric Blood Diseases, Tianjin Hematology Institute and Hospital, Tianjin, China[13]Department of Surgery, Taicang First People’s Hospital, Taicang, China[14]Department of Pediatric Oncology, Shanghai Xinhua Hospital, Shanghai, China[15]Laoting County Hospital, Laoting, China[16]Department of Hematology, Zhejiang University School of Medicine Children’s Hospital, Hangzhou, China[17]Department of Neurosurgery, Tiantan Hospital, Beijing, China重点科室诊疗科室神经外科首都医科大学附属天坛医院[18]Department of Hematology/Oncology, Fudan University Children’s Hospital, Shanghai, China[19]Department of Pediatric Hematology/Oncology, Peking University Renmin Hospital, Beijing, China
Objective To determine the feasibility of long-term prospective follow-up and ascertainment of cancer in offspring and mothers from the 1993-1995 Chinese Community Intervention Program that provided folic acid supplements before and during early pregnancy to reduce neural tube defects. Design Feasibility pilot study for a prospective cohort study. Setting Families residing during 2012-2013 in one rural and one urban county from 21 counties in 3 provinces in China included in the Community Intervention Program campaign. Participants The feasibility study targeted 560 families, including 280 from the rural and 280 from the urban county included in the large original study; about half of mothers in each group had taken and half had not taken folic acid supplements. Intervention The planned new study is observational. Primary and secondary outcome measures Primary: incidence of paediatric cancers in offspring; secondary: other chronic diseases in offspring and chronic diseases in mothers Results Only 3.4% of pilot study families could not be found, 3.9% had moved out of the study area and 8.8% refused to participate. Interviews were completed by 82% of mothers, 79% of fathers and 83% of offspring in the 560 families. Almost all mothers and offspring who were interviewed also participated in anthropometric measurements. We found notable urban-rural differences in sociodemographic and lifestyle characteristics of the parents, but fewer differences among the offspring. In eight catchment area hospitals, we identified a broad range of paediatric cancers diagnosed during 1994-2013, although paediatric brain tumours, lymphomas and rarer cancers were likely under-represented. Conclusions Overall, 20 years after the original Community Intervention Program, the pilot study achieved high levels of follow-up and family member interview participation, and identified substantial numbers of paediatric malignancies during 1994-2013 in catchment area hospitals. Next steps and strategies for overcoming limitations are described.
基金：
Intramural Research Program of the National Institutes of Health, National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI); US Public Health Service of the Department of Health and Human Services; US Centers for Disease Control and PreventionUnited States Department of Health & Human ServicesCenters for Disease Control & Prevention - USA [U01 GH0000029, 5U 19 GH000636]; Chinese Center for Disease Control and Prevention
第一作者机构：[1]Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
共同第一作者：
通讯作者：
通讯机构：[1]Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
推荐引用方式(GB/T 7714)：
Linet Martha S.,Wang Linhong,Wang Ning,et al.Prospective investigation of folic acid supplements before and during early pregnancy and paediatric and adult cancers in the Chinese children and families cohort: a pilot study in a sample of rural and urban families[J].BMJ OPEN.2018,8(7):-.doi:10.1136/bmjopen-2018-022394.
APA：
Linet, Martha S.,Wang, Linhong,Wang, Ning,Berry, Robert J.,Chao, Ann...&Wang, Yu.(2018).Prospective investigation of folic acid supplements before and during early pregnancy and paediatric and adult cancers in the Chinese children and families cohort: a pilot study in a sample of rural and urban families.BMJ OPEN,8,(7)
MLA：
Linet, Martha S.,et al."Prospective investigation of folic acid supplements before and during early pregnancy and paediatric and adult cancers in the Chinese children and families cohort: a pilot study in a sample of rural and urban families".BMJ OPEN 8..7(2018):-
