Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy
机构：[1]Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China内科系统骨髓移植中心浙江大学医学院附属第一医院[2]Innovative Cellular Therapeutics Co., Ltd., Shanghai, China[3]PET/CT Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China医技科室PET中心浙江大学医学院附属第一医院[4]Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China诊疗科室血液科首都医科大学附属天坛医院
Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications.
基金：
973 ProgramNational Basic Research Program of China [2015-CB964900]; Natural Science Foundation of ChinaNational Natural Science Foundation of China [81230014, 81470341, 81500157, 81770201, 81730008]; Key Project of Science and Technology Department of Zhejiang Province [2015C03G2010091]
第一作者机构：[1]Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China[2]Innovative Cellular Therapeutics Co., Ltd., Shanghai, China[*1]Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, China[*2]Innovative Cellular Therapeutics Co., Ltd., Room 201, Building 4, 998 Halei Road, Shanghai, 201203, China
推荐引用方式(GB/T 7714)：
Hu Yongxian,Wang Jiasheng,Pu Chengfei,et al.Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy[J].CANCER RESEARCH AND TREATMENT.2018,50(4):1462-1466.doi:10.4143/crt.2017.473.
APA：
Hu, Yongxian,Wang, Jiasheng,Pu, Chengfei,Zhao, Kui,Cui, Qu...&Huang, He.(2018).Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy.CANCER RESEARCH AND TREATMENT,50,(4)
MLA：
Hu, Yongxian,et al."Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy".CANCER RESEARCH AND TREATMENT 50..4(2018):1462-1466
