机构：[1]Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, No. 56 Nanlishi Road, Beijing 100045, China职能科室临床流行病与循证医学中心首都医科大学附属北京儿童医院[2]Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing 100045, China临床科室耳鼻咽喉头颈外科首都医科大学附属北京儿童医院[3]Department of Pathology, Beijing Children’s Hospital, Capital Medical University, Beijing, China医技科室病理科首都医科大学附属北京儿童医院
BackgroundThe incidence of thyroid cancer is fast increasing in both adults and children. The pediatric thyroid cancer had often already progressed to a more advanced stage of the disease at diagnosis. Early detection of pediatric thyroid cancer has been a problem for many years. Lipocalin-2 (Lcn2) has been reported to be over-expressed in cancers of diverse histological origin and it facilitates tumorigenesis by promoting survival, growth, and metastasis.MethodsThe plasma Lcn2 concentration of 28 Chinese papillary thyroid cancer (PTC) children and 24 healthy controls was measured. Immunostaining for Ki-67 of tumor tissue from PTC children was performed. The expression levels of Lcn2 and NFB in PTC tissue and peri-carcinoma tissue of PTC children were measured through Western blot.ResultsThe plasma concentration of Lcn2 was significantly elevated in pediatric PTC patients compared with healthy controls. Besides, the plasma Lcn2 concentration significantly correlated with clinical characteristics, NFB level, and Ki-67 positive rate of nucleus in tissue of PTC.ConclusionThis is the first study to evaluate the plasma Lcn2 in pediatric PTC patients. It is possible that the plasma Lcn2 may be a new biomarker of pediatric thyroid cancer. Further studies are needed to explore the definite role and mechanism of Lcn2 in thyroid cancer, which will help to explore novel diagnostic or therapeutic strategies.
基金：
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding [ZYLX201508]; Beijing Municipal Science and Technology Project [Z151100003715006]
第一作者机构：[1]Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, No. 56 Nanlishi Road, Beijing 100045, China[2]Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing 100045, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, No. 56 Nanlishi Road, Beijing 100045, China[2]Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing 100045, China
推荐引用方式(GB/T 7714)：
Tai Jun,Wang Shengcai,Zhang Jie,et al.Up-regulated lipocalin-2 in pediatric thyroid cancer correlated with poor clinical characteristics[J].EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY.2018,275(11):2823-2828.doi:10.1007/s00405-018-5118-x.
APA：
Tai, Jun,Wang, Shengcai,Zhang, Jie,Ge, Wentong,Liu, Yuanhu...&Ni, Xin.(2018).Up-regulated lipocalin-2 in pediatric thyroid cancer correlated with poor clinical characteristics.EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY,275,(11)
MLA：
Tai, Jun,et al."Up-regulated lipocalin-2 in pediatric thyroid cancer correlated with poor clinical characteristics".EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 275..11(2018):2823-2828
