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Deep Brain Stimulation at Variable Frequency to Improve Motor Outcomes in Parkinson's Disease

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机构： [1]National Engineering laboratory for Neuromodulation, Tsinghua University, Beijing, China [2]University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA [3]Department of Neurosurgery, University of Florida, Gainesville, FL, USA [4]Beijing Tiantan Hospital, Capital Medical University, Beijing, China [5]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China [6]Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Shenzhen, China [7]Man-machine-environment engineering Institute, School of Aerospace Engineering, Tsinghua university, Beijing, China [8]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China

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Introduction Deep brain stimulation (DBS) with high frequency (HFS) is a well-established therapy for Parkinson's disease (PD); however, low frequency DBS (LFS) may control axial symptoms including freezing of gait (FOG). We conducted a pilot safety and feasibility study to examine if a novel DBS paradigm of variable frequency stimulation (VFS) that combined HFS and LFS would capture a broader set of motor symptoms. MethodsResultsFour PD patients with bilateral STN DBS and FOG were enrolled. A UPDRS III and 10m timed up and go (TUG) task were performed off medications-off DBS and then one hour after HFS and one hour after VFS programming. The UPDRS III motor score improved by additional 14% during VFS setting when compared to HFS. VFS also increased gait speed (mean change 45%) and reduced the number of freezing episodes (mean change 58%). ConclusionsVFS improves UPDRS and FOG in PD when compared to HFS.Copyright (c) 2018 International Parkinson and Movement Disorder Society

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大类 | 4 区医学

小类 | 4 区临床神经病学

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第一作者机构： [1]National Engineering laboratory for Neuromodulation, Tsinghua University, Beijing, China

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通讯机构： [1]National Engineering laboratory for Neuromodulation, Tsinghua University, Beijing, China [2]University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA [6]Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Shenzhen, China [7]Man-machine-environment engineering Institute, School of Aerospace Engineering, Tsinghua university, Beijing, China [8]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China [*1]University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA [*2]National Engineering laboratory for Neuromodulation, Tsinghua University, Beijing, China

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