机构：[1]Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing TiantanHospital, CapitalMedical University[2]Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College[3]Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine[4]Department of Nuclear Medicine, Beijing Tiantan Hospital, Beijing, China医技科室核医学科首都医科大学附属天坛医院[5]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD[6]Department of Radiology, Stanford University, Stanford, CA.
Objectives Uncommon pathological subtypes of meningioma may present with severe peritumoral brain edema and mimic high-grade glioma (HGG). In a prospective cohort study of Ga-68-NOTA-PRGD2 PET/CT to evaluate glioma, we occasionally observed that a combination of Ga-68-NOTA-PRGD2 and F-18-FDG was able to differentiate these 2 lesion types. Methods From 2013 to 2016, 21 patients suspected of HGG by MRI were recruited for evaluation using Ga-68-NOTA-PRGD2 PET/CT. Brain F-18-FDG PET/CT was performed within 3 days for comparison, and the tumor was surgically removed. The PET results were compared with integrin v3 expression and microvascular density quantification of tumor samples. Results Of the 21 recruited patients, 5 patients were finally pathologically diagnosed as uncommon meningioma with severe peritumoral brain edema, including chordoid meningioma (n = 1), angiomatous meningioma (n = 1), and mixed angiomatous and microcystic meningioma (n = 3). Sixteen were diagnosed as HGG. All the meningioma lesions (n = 5) exhibited intense and homogeneous Ga-68-NOTA-PRGD2 uptake with higher SUVmax on Ga-68-NOTA-PRGD2 PET (1.64-7.86; mean SD, 4.23 +/- 2.48) than the HGG lesions (0.81-2.99; mean +/- SD, 1.57 +/- 0.33; P = 0.0047). Moreover, the uptake ratios of Ga-68-NOTA-PRGD2 over F-18-FDG, normalized as lg100 * SUVmax (RGD / FDG), in the uncommon meningiomas were significantly higher than those in HGG (1.87 +/- 1.36 vs 1.04 +/- 0.87, P = 0.0001). A cutoff value of 1.58 was able to discriminate between these lesion types. There were positive correlations among the expression level of integrin v3, microvascular density, and the tumor-to-background ratio derived from Ga-68-NOTA-PRGD2 PET (P < 0.05). Conclusions This study reveals a specific imaging pattern of uncommon meningioma mimicking HGG, in which Ga-68-NOTA-PRGD2 PET provided added value to F-18-FDG PET.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81741142, 81701742, 81601551, 81502156, 81371596]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2014BAI04B01]; Key Project on Inter-Governmental International Scientific and Technological Innovation Cooperation in National Key Projects of Research and Development Plan [2016YFE0115400]; Chinese Academy of Medical Science Major Collaborative Innovation Project [2016-I2M-1-011]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7161012]; Peking Union Medical College Youth Fund; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2017320003]; Beijing Key Laboratory of Brain Tumor Project; National Institute of Biomedical Imaging and BioengineeringUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB); National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA
第一作者机构：[1]Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing TiantanHospital, CapitalMedical University
共同第一作者：
通讯作者：
通讯机构：[2]Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College[3]Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine[5]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD[*1]Department of NuclearMedicine, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing 100730, China.[*2]National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 35A Convent Dr, GD937, Bethesda, MD 20892
推荐引用方式(GB/T 7714)：
Li Deling,Zhang Jingjing,Ji Nan,et al.Combined 68Ga-NOTA-PRGD2 and 18F-FDG PET/CT Can Discriminate Uncommon Meningioma Mimicking High-Grade Glioma[J].CLINICAL NUCLEAR MEDICINE.2018,43(9):648-654.doi:10.1097/RLU.0000000000002233.
APA：
Li, Deling,Zhang, Jingjing,Ji, Nan,Zhao, Xiaobin,Zheng, Kun...&Chen, Xiaoyuan.(2018).Combined 68Ga-NOTA-PRGD2 and 18F-FDG PET/CT Can Discriminate Uncommon Meningioma Mimicking High-Grade Glioma.CLINICAL NUCLEAR MEDICINE,43,(9)
MLA：
Li, Deling,et al."Combined 68Ga-NOTA-PRGD2 and 18F-FDG PET/CT Can Discriminate Uncommon Meningioma Mimicking High-Grade Glioma".CLINICAL NUCLEAR MEDICINE 43..9(2018):648-654
