机构：[1]Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima City, Japan[2]Department of Pathology and Oncology, Research Field inMedicine andHealth Sciences, Medical and Dental Sciences Area, Research and Education Assembly, KagoshimaUniversity, KagoshimaCity, Japan[3]Department of Pathology, National Center for Children Health and Development, Tokyo, Japan
Aims and objectives: Fish oil (FO) lipid emulsion and a new lipid emulsion (SMOF) are important treatments for intestinal failure-associated liver disease. We evaluated the efficacy of FO and SMOF lipid emulsion on intestinal mucosal adaptation using a total parenteral nutrition (TPN)-supported rat model of short bowel syndrome. Material & methods: Sprague-Dawley rats underwent jugular vein catheterization and 90% small bowel resection and were divided into three groups: TPN with soy bean oil lipid emulsion (SO group), FO lipid emulsion (FO group), or SMOF (SMOF group). On day 13, the rats were euthanized, and the small intestine was harvested. The microscopic morphology and crypt cell proliferation rate (CCPR) were then evaluated. Results: The villus height of the ileumin the SMOF group was significantly higher than in the SO group. The crypt depth of the intestine in the SMOF group was significantly lower than in the SO group. The CCPRs of the intestine in the FO and SMOF groups were both higher than in the SO group. Conclusions: Lipid emulsion affected the bowel morphology, such as the mucosa as well as the intestinal smooth muscle. Further studies are needed to clarify the mechanisms. (C) 2018 Elsevier Inc. All rights reserved.
基金：
Facility of Laboratory Animal Science Research Support Center Institute for Research Promotion Kagoshima University; Japan Society for the Promotion of Science (JSPS)Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [16K10466, 16K10094, 16K10095, 16K10434, 16H07090, 17K10555, 17K11514, 17K10183, 17K11515, 17K10180]; Kagoshima Prefecture Medical Association
第一作者机构：[1]Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima City, Japan
通讯作者：
通讯机构：[1]Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima City, Japan[*1]Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima City, 890-8520, Japan.
推荐引用方式(GB/T 7714)：
Onishi Shun,Kaji Tatsuru,Machigashira Seiro,et al.The effect of intravenous lipid emulsions and mucosal adaptation following massive bowel resection[J].JOURNAL OF PEDIATRIC SURGERY.2018,53(12):2444-2448.doi:10.1016/j.jpedsurg.2018.08.019.
APA：
Onishi, Shun,Kaji, Tatsuru,Machigashira, Seiro,Yamada, Waka,Masuya, Ryuta...&Ieiri, Satoshi.(2018).The effect of intravenous lipid emulsions and mucosal adaptation following massive bowel resection.JOURNAL OF PEDIATRIC SURGERY,53,(12)
MLA：
Onishi, Shun,et al."The effect of intravenous lipid emulsions and mucosal adaptation following massive bowel resection".JOURNAL OF PEDIATRIC SURGERY 53..12(2018):2444-2448
