机构：[1]Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P.R. China[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, P.R. China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院
Leukoaraiosis, also referred to as white-matter hyperintensities (WMHs) or age-related white matter changes, is the most frequently seen lesion on brain magnetic resonance images (MRI) in the elderly. LA is a subject of intense research interest, and is correlated with stroke, cognitive impairment or dementia, disturbances, affective disorders, and poor prognoses. Rapid advances in neuroimaging have enabled greater understanding of LA associated with aging-related cognitive decline or dementia. Recently, the techniques of multimodal MRI, such as structural MRI (sMRI), resting-state functional MRI (rs-MRI), cerebrovascular reactivity (CVR), diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS), and dynamic contrast-enhanced MRI (DCE-MRI), have been used to explore the underlying mechanism of cognitive impairment in patients with LA. These multimodal MRI techniques may provide further insights into the structural and functional changes of LA with cognitive dysfunction.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81301016, 81371201]; Beijing Municipal Administration of Hospitals' Youth Programme [QML20150303]
第一作者机构：[1]Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P.R. China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P.R. China[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, P.R. China
推荐引用方式(GB/T 7714)：
Yuan Junliang,Feng Li,Hu Wenli,et al.Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis[J].MEDICAL SCIENCE MONITOR.2018,24:8910-8915.doi:10.12659/MSM.912153.
APA：
Yuan, Junliang,Feng, Li,Hu, Wenli&Zhang, Yumei.(2018).Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis.MEDICAL SCIENCE MONITOR,24,
MLA：
Yuan, Junliang,et al."Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis".MEDICAL SCIENCE MONITOR 24.(2018):8910-8915
