机构：[1]Beijing Ophthalmology & Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属同仁医院[2]Department of Ophthalmology, The First Hospital of Lanzhou University, Chengguan District, Lanzhou Gansu, China[3]Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属同仁医院[4]Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China临床科室职能科室临床流行病与循证医学中心眼科首都医科大学附属北京儿童医院[5]Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY.
Purpose:To retrospectively investigate the indications and outcomes of pediatric penetrating keratoplasty (PKP) and to explore factors that affect graft survival.Methods:Patients who had undergone PKP from May 2010 to December 2016, aged 12 years were categorized as infants (3 months and <4 years) or children (4 years and 12 years). Clinical data including patient demographics, indications, surgical procedures, postoperative follow-up, and graft clarity were recorded and analyzed.Results:Among 160 eyes of 146 patients, 79 eyes and 81 eyes were treated from the infant and child groups, respectively, and followed up for 33.7 21.7 months (range, 6 months to 7 years). The most common indication for PKP was congenital corneal opacity (71.9%). The survival rate of all corneal grafts was 68.1%. The rejection reaction rate was 33.8%. More children than infants underwent PKP that was combined with other intraocular surgeries (P < 0.05). The graft failures were in the regraft (52.0%), congenital opacities (30.4%), and acquired opacities (15.0%) groups. The rate of graft failure in patients who received PKP combined with other intraocular surgery (40.0%) was higher than those who received PKP only (30.0%). The univariate logistic regression analysis revealed that the graft failure was associated with the graft indication (P < 0.05).Conclusions:The most common indication for PKP in children younger than 12 years was congenital corneal opacity in Beijing, China. The graft survival was 68.1%, with a mean follow-up of 33.7 months. Graft failure was associated with the indication.
基金：
National Natural Scientific Foundation of ChinaNational Natural Science Foundation of China [81541105]; Research to Prevent BlindnessResearch to Prevent Blindness (RPB)
第一作者机构：[1]Beijing Ophthalmology & Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Beijing Ophthalmology & Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye bank, Dongjiaominxiang 1#, Dongcheng District, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Zhang Yingnan,Liu Yang,Liang Qingfeng,et al.Indications and Outcomes of Penetrating Keratoplasty in Infants and Children of Beijing, China[J].CORNEA.2018,37(10):1243-1248.doi:10.1097/ICO.0000000000001695.
APA：
Zhang, Yingnan,Liu, Yang,Liang, Qingfeng,Miao, Sen,Lin, Qi...&Lu, Qingxian.(2018).Indications and Outcomes of Penetrating Keratoplasty in Infants and Children of Beijing, China.CORNEA,37,(10)
MLA：
Zhang, Yingnan,et al."Indications and Outcomes of Penetrating Keratoplasty in Infants and Children of Beijing, China".CORNEA 37..10(2018):1243-1248
