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Association of polymorphism in the VEGFA gene 3′-UTR +936T/C with susceptibility to biliary atresia in a Southern Chinese Han population

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机构: [1]Southern Medical University, Guangzhou, Guangdong [2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong [3]Department of Anesthesiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong [4]Division of Neonatology, Affiliated BaYi Children’s Hospital, Clinical Medical College in PLAArmy General Hospital, Southern Medical University, Beijing, China [5]National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing, China [6]Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China
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关键词: biliary atresia GWAS polymorphism susceptibility VEGF

摘要:
Background: Biliary atresia (BA) is a neonatal disease characterized by chronic inflammation of the bile ducts and progressive aggravation of jaundice, but with a poor prognosis and high mortality. The etiology of BA is still uncertain which may be related to gene defect, virus infection, immune disorder, gene polymorphism. As a proinflammatory cytokine, VEGFA gene polymorphism (rs3025039) has been shown to be related to the pathogenesis of BA in Taiwanese population. Methods: We investigated the association between VEGFA gene polymorphism (rs3025039) and BA susceptibility using the largest case-control cohort, totaling with 506 BA patients and 1473 healthy controls in a Southern Chinese Han population. VEGFA gene polymorphism (rs3025039) was genotyped using the MassARRAY iPLEX Gold system (Sequenom). Odds ratios (OR) and 95% confidence intervals (CIs) were used to access the association between the VEGFA gene polymorphism (rs3025039) and BA risk. Results: No significant association was found between the VEGFA gene polymorphism (rs3025039) and BA risk in the overall analysis. Conclusion: These results suggest that VEGFA gene polymorphism (rs3025039) may not be associated with the risk of BA in the Southern Chinese Han population. © 2017 Wiley Periodicals, Inc.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 医学实验技术
最新[2023]版:
大类 | 4 区 医学
小类 | 3 区 医学实验技术
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第一作者机构: [1]Southern Medical University, Guangzhou, Guangdong [2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong
通讯作者:
通讯机构: [1]Southern Medical University, Guangzhou, Guangdong [4]Division of Neonatology, Affiliated BaYi Children’s Hospital, Clinical Medical College in PLAArmy General Hospital, Southern Medical University, Beijing, China [5]National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing, China [6]Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China [*1]Division of Neonatology, Affiliated BaYi Children’s Hospital, Clinical Medical College in PLAArmy General Hospital, Southern Medical University, Beijing, China.
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