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Treatment of hyperoxia-induced lung injury with lung mesenchymal stem cells in mice

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机构： [1]Department of Pediatrics, Affiliated BaYi Children’s Hospital, PLA Army General Hospital, Beijing, China [2]The National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing, China [3]Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China [4]Department of Pediatrics, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China [5]Neonatal Intensive Care Unit of Jining No. 1 People’s Hospital, Jining, Shangdong Province, China

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Objective. Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm neonates and has no effective treatment. This study aimed to investigate the therapeutic effects of neonatal mouse lung resident mesenchymal stem cells (L-MSCs) on the hyperoxia-induced lung injury. Methods. L-MSCs were separated and identified according to the MSC criterions. Hyperoxia-Induced Lung Injury (HILI) of neonatal KM mice was induced with hyperoxia (FiO2 = 60%) and investigated with pathological methods. Neonatal KM mice were divided into 3 groups (hyperoxia + L-MSC group, hyperoxia + PBS group, and air control group). Mice in the hyperoxia + L-MSC group were treated with L-MSCs at 3, 7, and 14 days after birth. After hyperoxia exposure for 21 days, the lung pathology, Radial Alveolar Count (RAC), CD31 expression, and vascular endothelial growth factor (VEGF) expression were investigated. Results. After hyperoxia exposure, the body weight, RAC, CD31 expression, and VEGF expression in the hyperoxia + L-MSC group were significantly better than those in the hyperoxia + PBS group but inferior to those in the air control group significantly. These indicate L-MSCs are partially protective on the lung injury of mice with hyperoxia-induced BPD. Conclusion. L-MSCs are helpful for the prevention and treatment of BPD, and endogenous L-MSCs may play a role in the postinjury repair of the lung. Copyright © 2018 Yabo Mei et al.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区细胞与组织工程

最新[2023]版：

大类 | 3 区医学

小类 | 3 区细胞与组织工程

第一作者：

第一作者机构： [1]Department of Pediatrics, Affiliated BaYi Children’s Hospital, PLA Army General Hospital, Beijing, China [2]The National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing, China [3]Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China

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通讯作者：

通讯机构： [1]Department of Pediatrics, Affiliated BaYi Children’s Hospital, PLA Army General Hospital, Beijing, China [2]The National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing, China [3]Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China

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