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Altered functional connectivity strength in informant-reported subjective cognitive decline: A resting-state functional magnetic resonance imaging study

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机构： [a]School of Biological Science and Medical Engineering, Beihang University, Beijing, China [b]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China [c]Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China [d]Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia [e]Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia [f]Beijing TianTan Hospital, Capital Medical University, Beijing, China [g]Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia

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关键词： Aging Functional connectivity strength Preclinical Alzheimer's disease Precuneus Subjective cognitive decline

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Introduction: Informant-reported subjective cognitive decline (iSCD) has been associated with a higher risk of conversion to dementia, but the findings of whole brain functional connectivity strength (FCS) changes in iSCD are limited. Methods: The sample comprised 39 participants with iSCD and 39 age- and sex- matched healthy controls. The global absolute (aFCS) and relative functional connectivity strengths were estimated using weighted degree centrality and the z-scores of the weighted degree centrality respectively. FreeSurfer was used for measuring cortical thickness. Results: The aFCS was lower in iSCD primarily in left medial superior frontal, left precuneus, left parietal, right cuneus, and bilateral calcarine; while relative functional connectivity strength was higher in posterior cingulate cortex/precuneus compared with healthy controls. No significant differences in cortical thickness were observed. Discussion: There are detectable changes of FCS in iSCD, with the precuneus possibly playing a compensatory role. FCS could therefore have a potential role to serve as one of the earliest neuroimaging markers of neurodegenerative disease. © 2018 The Authors

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第一作者机构： [a]School of Biological Science and Medical Engineering, Beihang University, Beijing, China

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通讯机构： [a]School of Biological Science and Medical Engineering, Beihang University, Beijing, China [b]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China [c]Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China

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