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Adjustable Polyurethane Foam as Filling Material for a Novel Spondyloplasty: Biomechanics and Biocompatibility.

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机构： [1]Department of Neurosurgery, University Hospital of Dresden, Dresden, Germany [2]University Comprehensive Spine Center, University Hospital of Dresden, Dresden, Germany [3]Department of Orthopedic Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China [4]Minimal Invasive Spine Surgery Center, Chinese PLA General Hospital, Beijing, China [5]Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA [6]Institute of Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany [7]Department of Neurosurgery, Medical University of Graz, Graz, Austria [8]Department of Biomedical Engineering, Technical University of Kosice, Kosice, Slovakia [9]Innovent e.V., Biomaterials Department, Jena, Germany [10]Research Unit for Experimental Neurotraumatology, Medical University of Graz, Graz, Austria [11]Lütten Klein Clinic, Rostock, Germany [12]Task Force Prospective Spine, Cologne, Germany [13]Short Care Clinic, Greifswald, Germany

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To investigate the biomechanics and biocompatibility of polyurethane (PU) foam with adjustable stiffness as a filling material for a novel spondyloplasty that is designed to reduce the risk of postoperative adjacent level fractures. Sixty individual porcine lumbar vertebrae were randomly split into 4 groups: A, B, C, and D. Group A served as unmodified vertebral body controls. Groups B, C, and D consisted of hollowed vertebral bodies. Vertebrae of groups C and D were filled with adjustable PU foams of different stiffness. The compressive strength and stiffness of vertebrae from groups A-D were recorded and analyzed. 3T3 mouse fibroblasts were cultured with preformed PU foams for 4 days to test biocompatibility. The strength and stiffness of the hollowed groups were lower than in group A. However, the differences were not statistically significant between group A and group C (P > 0.05), and were obviously different between group A and group B or group D (P < 0.01 and <0.05, respectively). Moreover, the strength and stiffness after filling foams in group C or group D were significantly greater than in group B (P < 0.01 and <0.05, respectively). Live/dead staining of 3T3 cells confirmed the biocompatibility of the PU foam. The new PU foam shows adaptability regarding its stiffness and excellent cytocompatibility in vitro. The results support the clinical translation of the new PU foams as augmentation material in the development of a novel spondyloplasty. Copyright © 2018 Elsevier Inc. All rights reserved.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区外科

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区外科

第一作者：

第一作者机构： [1]Department of Neurosurgery, University Hospital of Dresden, Dresden, Germany [2]University Comprehensive Spine Center, University Hospital of Dresden, Dresden, Germany [3]Department of Orthopedic Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China [4]Minimal Invasive Spine Surgery Center, Chinese PLA General Hospital, Beijing, China

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通讯作者：

通讯机构： [1]Department of Neurosurgery, University Hospital of Dresden, Dresden, Germany [2]University Comprehensive Spine Center, University Hospital of Dresden, Dresden, Germany [11]Lütten Klein Clinic, Rostock, Germany [12]Task Force Prospective Spine, Cologne, Germany [13]Short Care Clinic, Greifswald, Germany

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