国家自然科学基金项目(81371201)%国家重点基础研究发展计划(973 计划)青年科学家项目(2013CB837300)%首都医科大学基础与临床合作重点项目(16JL03)National Nature Science Foundation of China(81371201)%National Basic Research Program of China(973 Project)Young Scientist Project(2013CB837300)%Capital Medical University Foundation and Clinical Collaboration Key Project(16JL03)