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Netrin-1 Overexpression Improves Neurobehavioral Outcomes and Reduces Infarct Size Via Inhibition of the Notch1 Pathway Following Experimental Stroke

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收录情况： ◇ SCIE

作者：

机构： [1]Shanghai Jiao Tong Univ, XinHua Hosp, Dept Neurosurg, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China; [2]Zhejiang Univ, Dept Neurosurg, Med Coll, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China; [3]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China

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关键词： Netrin-1 middle cerebral artery occlusion Notch1 pathway neurobehavioral

摘要：

Stroke is a leading cause of morbidity and mortality worldwide. Administration of Netrin-1 during the peri-infarct period has been shown to decrease infarct size in rats; however, the underlying mechanism is unclear. We addressed this question in the present study by inducing stroke in rats via middle cerebral artery occlusion (MCAO), and evaluating the effects of Netrin-1 treatment by neurobehavioral testing, immunocytochemistry, and western blotting. Netrin-1 overexpression increased neurobehavioral test scores and reduced cerebral infarct volume following MCAO via inhibition of the Notch1 signaling pathway. These results demonstrate that early administration of Netrin-1 can is an effective therapeutic approach for improving outcome after stroke. (C) 2017 Wiley Periodicals, Inc.

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出版当年[2016]版：

大类 | 3 区医学

小类 | 4 区神经科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2015]版：

Q3 NEUROSCIENCES

最新[2024]版：

Q2 NEUROSCIENCES

影响因子： 3.4 最新[2024版] 4 最新五年平均 2.689 出版当年[2015版] 2.585 出版当年五年平均 2.594 出版前一年[2014版] 2.481 出版后一年[2016版]

第一作者：

第一作者机构： [1]Shanghai Jiao Tong Univ, XinHua Hosp, Dept Neurosurg, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;

通讯作者：

通讯机构： [1]Shanghai Jiao Tong Univ, XinHua Hosp, Dept Neurosurg, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;

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