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Clinical characteristics and prognosis of pediatric cryptococcosis in Beijing Children's Hospital, 2002-2014

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机构: [1]Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Pediat Resp Infect Dis,Dept Infec, Key Lab Major Dis Children,Minist Educ,Natl Clin, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Pediat Resp Infect Dis,Dept Infec, Natl Key Discipline Pediat,Minist Educ,Natl Clin, Beijing 100045, Peoples R China; [3]Capital Med Univ, Beijing Key Lab Pediat Resp Infect Dis,Beijing Pe, Natl Clin Res Ctr Resp Dis,Beijing Childrens Hosp, Key Lab Major Dis Children,Minist Educ,Lab Microb, Beijing, Peoples R China; [4]Capital Med Univ, Beijing Key Lab Pediat Resp Infect Dis,Beijing Pe, Natl Clin Res Ctr Resp Dis,Beijing Childrens Hosp, Natl Key Discipline Pediat,Minist Educ,Lab Microb, Beijing, Peoples R China; [5]Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, Beijing, Peoples R China
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关键词: Cryptococcosis Pediatrics Clinical characteristics Prognosis

摘要:
Cryptococcosis is a rare pediatric disease. The aim of the study is to describe clinical characteristics and prognosis of pediatric cryptococcosis from 2002 to 2014 in Beijing Children's Hospital. A total of 53 cases of cryptococcosis were identified, 69.8% of which were males. The mean age was 7 years. Forty-one (77.4%) patients had no underlying conditions. Fever, headache, and vomiting were the most common symptoms. The most common sites were the central nervous system (CNS), followed by the lungs. Most patients received a combination of amphotericin B and fluconazole with or without flucytosine as their initial regimen. Twenty-seven patients received a follow-up and six patients (22.2%) had died. The factors associated with neurological complications or death were headache (P = 0.008), seizures (P = 0.006), visual impairment (P = 0.011), neck stiffness (P = 0.008), low erythrocyte sedimentation rate (ESR) (P = 0.024), and a cerebral spinal fluid (CSF) cryptococcal antigen titer >= 1:1024 (P = 0.038). Conclusions: The majority of cryptococcosis cases in China occurred in children without underlying conditions, causing multiple organ damage. The CNS was the most common site. Patients who had headaches, seizures, or high CSF antigen titers experienced neurological complications or died. What is known: Cryptococcosis is a rare cause of infection in children. What is new: This review gives a brief overview over pediatric cryptococcosis in China

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出版当年[2016]版:
大类 | 4 区 医学
小类 | 3 区 儿科
最新[2023]版:
大类 | 3 区 医学
小类 | 2 区 儿科
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出版当年[2015]版:
Q2 PEDIATRICS
最新[2023]版:
Q1 PEDIATRICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者机构: [1]Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Pediat Resp Infect Dis,Dept Infec, Key Lab Major Dis Children,Minist Educ,Natl Clin, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Pediat Resp Infect Dis,Dept Infec, Natl Key Discipline Pediat,Minist Educ,Natl Clin, Beijing 100045, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Pediat Resp Infect Dis,Dept Infec, Key Lab Major Dis Children,Minist Educ,Natl Clin, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Pediat Resp Infect Dis,Dept Infec, Natl Key Discipline Pediat,Minist Educ,Natl Clin, Beijing 100045, Peoples R China;
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