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External Validation of Pooled Cohort Risk Equations to Predict 1-Year Clinical Outcome in Ischemic Stroke Patients

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收录情况: ◇ SCIE

机构: [1]Capital Med Univ, Beijing Tiantan Hosp, Stroke Ctr, Beijing, Peoples R China; [2]Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Stroke Ctr, Beijing, Peoples R China; [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China; [5]Capital Med Univ, Beijing Shijitan Hosp, Dept Neurol, Beijing, Peoples R China
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关键词: Acute Ischemic Stroke Pooled Cohort Risk Equations Recurrence Transient Ischemic Attack

摘要:
Background: The present study aimed to validate the pooled cohort risk (PCR) equations in a Chinese ischemic stroke population and to explore its prognostic value in predicting stroke recurrence, coronary heart disease, and vascular death. Material/Method: Patients were selected from the China National Stroke Registry. The C statistic was used to examine the clinical prediction of the scores. To analyze the relevant risk factors, univariate and multivariate logistic regressions were performed. Results: Out of a total of 22 216 patients, 8287 patients (including 7652 acute ischemic stroke [AIS] and 635 transient ischemic attack [TIA] patients) were selected and enrolled in the study. At 1-year follow-up, for stroke recurrence rate, the C statistic value was 0.584 in AIS patients and 0.573 in all patients. For non-fatal myocardial infarction, the C statistic value was 0.533 in AIS patients and 0.493 in all patients. For vascular death, the C statistic value was 0.592 in AIS patients and 0.592 in all patients. For all events, the C statistic value was 0.582 in AIS patients and 0.575 in all patients. For AIS patients, the 12-month cumulative rates for recurrent stroke, vascular death, and combined vascular events were higher in the high-PCR group (PCR >= 20%). Conclusions: Pooled cohort risk equations may serve as potential tools to predict and stratify the 1-year risk of recurrent stroke and combined vascular events in AIS/TIA patients in China.

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出版当年[2016]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
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出版当年[2015]版:
Q3 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者:
第一作者机构: [1]Capital Med Univ, Beijing Tiantan Hosp, Stroke Ctr, Beijing, Peoples R China; [2]Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Stroke Ctr, Beijing, Peoples R China; [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China; [5]Capital Med Univ, Beijing Shijitan Hosp, Dept Neurol, Beijing, Peoples R China
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Tiantan Hosp, Stroke Ctr, Beijing, Peoples R China; [2]Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Stroke Ctr, Beijing, Peoples R China; [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;
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