Background and purpose Predictors of symptomatic intracranial hemorrhage (sICH) in Chinese patients with acute ischemic stroke treated with recombinant tissue plasminogen activator remain unclear. Methods Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) study were assessed to explore risk factors for symptomatic intracranial hemorrhage after intravenous thrombolysis. Three candidate sICH definitions were analyzed. Results Among 1128 patients with acute ischemic stroke treated with intravenous rtPA within 4.5 hours of symptom onset, 23 (2.0%), 44(3.9%) and 61 (5.4%) experienced modified mSITS-MOST, ECASS II, and NINDS defined sICH, respectively. Multivariate logistic regression revealed independent risk factors for sICH were age. 70 years-old(sICH per NINDS, adjusted OR = 1.73[95% CI1.02-2.95], p = 0.04), diabetes(sICH per SITS-MOST, adjusted OR = 3.50 [95% CI1.34-9.16], p = 0.01), serum glucose on admission >9.0mmol/L(sICH per ECASS II, adjusted OR = 2.84[95% CI1.48-5.46], p = 0.002), NIHSS on admission>20(sICH per SITS-MOST, adjusted OR = 5.06[95% CI1.68-15.20], p = 0.004 or sICH per NINDS, adjusted OR 2.81[95% CI1.42-5.57], p = 0.003) and cardioembolism(sICH per SITS-MOST, adjusted OR = 7.09[95% CI2.41-20.87], p<0.001 or sICH per ECASS II, adjusted OR = 4.99 [95% CI2.53-9.84], p<0.001) or sICH per NINDS, adjusted OR = 2.47[95% CI1.39-4.39], p = 0.002). Conclusion Cardioembolism, NIHSS on admission higher than 20, serum glucose on admission higher than 9.0 mmol/L and age >= 70 years were independent risk factors for symptomatic intracranial hemorrhage in Chinese patients with acute ischemic stroke treated with recombinant tissue plasminogen activator.
基金：
National Science and Technology Major Project of China [2011BA108602]; State Key Development Program of Basic Research of ChinaState Key Development Program for Basic Research of China [2009CB521905]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Ctr Stroke, Beijing, Peoples R China;[2]Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;[5]Capital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Ctr Stroke, Beijing, Peoples R China;[2]Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;[5]Capital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Liu Mingyong,Pan Yuesong,Zhou Lichun,et al.Predictors of post-thrombolysis symptomatic intracranial hemorrhage in Chinese patients with acute ischemic stroke[J].PLOS ONE.2017,12(9):-.doi:10.1371/journal.pone.0184646.
APA：
Liu, Mingyong,Pan, Yuesong,Zhou, Lichun&Wang, Yongjun.(2017).Predictors of post-thrombolysis symptomatic intracranial hemorrhage in Chinese patients with acute ischemic stroke.PLOS ONE,12,(9)
MLA：
Liu, Mingyong,et al."Predictors of post-thrombolysis symptomatic intracranial hemorrhage in Chinese patients with acute ischemic stroke".PLOS ONE 12..9(2017):-
