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High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack

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资源类型：

收录情况： ◇ SCIE

作者：
Rao, Zilong[1] * ; Zheng, Huaguang[2,3,4,5] ; Wang, Fei[6] ; Wang, Anxin[2,3,4,5] ; Liu, Liping[2,3,4,5] ; Dong, Kehui[2,3,4,5] ; Zhao, Xingquan[2,3,4,5] ; Cao, Yibin[1] ; Wang, Yilong[2,3,4,5] ;
机构： [1]Tangshan Gongren Hosp, Dept Neurol, 27 Wenhua Rd, Tangshan, Hebei, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili, Beijing, Peoples R China; [3]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [4]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China; [5]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China; [6]Tangshan Vocat & Tech Coll, Dept Informat Engn, Tangshan, Peoples R China
出处：
DOI： 10.1016/j.jstrokecerebrovasdis.2017.04.012
ISSN：

关键词： Minor stroke transient ischemic attack thromboelastography adenosine diphosphate maximum amplitude recurrent ischemic events

摘要：
Background: This study aimed to evaluate the relationship between thromboelastography adenosine diphosphate maximum amplitude (TEG-ADP(MA)) and recurrent ischemic events in patients with minor ischemic stroke or high-risk transient ischemic attack (TIA). Methods: A total of 265 patients received dual antiplatelet therapy were consecutively enrolled. High on-treatment platelet reactivity (HTPR) to ADP was assessed by TEG-ADPMA and detected the CYP2C19 genotype; recurrent ischemic events were followed up for 90 days after onset. The difference of recurrent ischemic events was analyzed with or without HTPR to ADP by the Kaplan-Meier, and further to determine the difference of recurrent ischemic events in each group according to TEG-ADPMA-based tertile distribution. Results: A total of 23 (8.6%) patients had recurrent ischemic events. TEG-ADPMA greater than or equal to 48 mm had good predictive value. Whether these patients were divided into 2 groups or 3 groups, the HTPR to ADP group had higher risk of recurrent ischemic events than the normal on-treatment platelet reactivity to ADP group by the Kaplan-Meier (all, P < .05). The tertile distribution map showed that the results of recurrent ischemic events were statistically significant in the third tertile group compared with the other two groups (all, P < .03); also, the third tertile group had a higher rate of carriers of at least 1 CYP2C19 reduced-function allele than the other two groups (P < .05). Conclusions: In patients with minor ischemic stroke and high-risk TIA, the TEG-ADPMA could predict recurrent ischemic events and has auxiliary effect on clinical decision-making.

基金：
Medical Science Research Project of Hebei provincial Health and Family Planning Commission [20170220]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81322019]; Beijing Institute for Brain Disorders [350011521303]; Beijing Science and Technology Project [Z141107002514125]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类 | 4 区 医学
小类 | 4 区 神经科学 4 区 外周血管病
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 神经科学 4 区 外周血管病
JCR分区：
出版当年[2015]版：
Q3 PERIPHERAL VASCULAR DISEASE Q4 NEUROSCIENCES
最新[2023]版：
Q3 NEUROSCIENCES Q3 PERIPHERAL VASCULAR DISEASE

影响因子： 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者：
第一作者机构： [1]Tangshan Gongren Hosp, Dept Neurol, 27 Wenhua Rd, Tangshan, Hebei, Peoples R China;
通讯作者：
通讯机构： [1]Tangshan Gongren Hosp, Dept Neurol, 27 Wenhua Rd, Tangshan, Hebei, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili, Beijing, Peoples R China; [3]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [4]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China; [5]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Rao Zilong,Zheng Huaguang,Wang Fei,et al.High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack[J].JOURNAL OF STROKE & CEREBROVASCULAR DISEASES.2017,26(10):2074-2081.doi:10.1016/j.jstrokecerebrovasdis.2017.04.012.
APA：
Rao, Zilong,Zheng, Huaguang,Wang, Fei,Wang, Anxin,Liu, Liping...&Wang, Yilong.(2017).High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,26,(10)
MLA：
Rao, Zilong,et al."High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 26..10(2017):2074-2081

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