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HLA-DRB1 and HLA-DQB1 alleles in Chinese Han patients with Juvenile-Onset recurrent respiratory papillomatosis

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收录情况： ◇ SCIE

作者：

机构： [1]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing Key Lab Pediat Dis Otolaryngol Head & Nec, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100045, Peoples R China; [3]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Key Lab Major Dis Children,Minist Educ, Beijing, Peoples R China; [4]Capital Med Univ, Beijing Childrens Hosp, Beijing 100045, Peoples R China

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关键词： Aggressive Chinese Han population HLA Human papilloma virus (HPV) Juvenile-Onset recurrent respiratory Papillomatosis (JORRP)

摘要：

Juvenile-Onset recurrent respiratory papillomatosis (JORRP) is a rare benign neoplasm of the respiratory mucosa caused by human papilloma virus. Previous studies on the possible associations between HLA alleles and JORRP have shown various results in different ethnic groups. The present study aims to investigate the association between JORRP and HLA class II DRBland DQB1 alleles in Chinese Han children. We found that the frequencies of HLA-DRB1*03:01 (p(c) = 0.0378, OR = 4.8) and HLA-DQB1 *02:01 (p(c) = 0.021, OR = 4.8) alleles were significantly higher in patients with JORRP than in controls. In addition, HLA-DRB1*03:01 allele significantly correlated with aggressive JORRP (r = 0.467, p = 0.009). This was the first study on the HLA alleles in Chinese Han patients with JORRP. Future studies are required to further elucidate the correlation of HLA class II alleles and susceptibility to JORRP. (C) 2017 Published by Elsevier Ireland Ltd.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区耳鼻喉科学 4 区儿科

最新[2023]版：

大类 | 4 区医学

小类 | 3 区儿科 4 区耳鼻喉科学

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出版当年[2015]版：

Q3 PEDIATRICS Q3 OTORHINOLARYNGOLOGY

最新[2023]版：

Q3 OTORHINOLARYNGOLOGY Q3 PEDIATRICS

影响因子： 1.2 最新[2023版] 1.5 最新五年平均 1.125 出版当年[2015版] 1.316 出版当年五年平均 1.186 出版前一年[2014版] 1.159 出版后一年[2016版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing Key Lab Pediat Dis Otolaryngol Head & Nec, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100045, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing Key Lab Pediat Dis Otolaryngol Head & Nec, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100045, Peoples R China; [4]Capital Med Univ, Beijing Childrens Hosp, Beijing 100045, Peoples R China

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