机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Pathol, Beijing, Peoples R China;首都医科大学附属天坛医院[2]Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China;[3]Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pathol, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China;[4]Tsinghua Univ, Peking Union Med Coll, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China
Purpose: This meta-analysis study aimed to reveal the prognostic relevance of ubiquitin-specific protease 22 (USP22) expression in patients with cancers. Methods: PubMed, Embase, and the Cochrane Library electronic databases were searched for relevant studies published up to April 2017. The prognostic value of USP22 expression was evaluated by hazard ratio with 95% confidence intervals (CIs). Relative risk (RR) with 95% CIs assessed the effects of USP22 expression on clinicopathological parameters. A total of 16 studies of 2,233 Chinese patients were included in the final meta-analysis. Results: A significant association was found between USP22 overexpression and survival in patients with cancers. The pooled RR indicated that USP22 overexpression was related to histological grade, advanced tumor-node-metastasis stage, positive lymph node metastasis, and distant metastasis. Conclusion: This meta-analysis demonstrated that USP22 could be a novel biomarker for predicting prognosis in patients with cancers in the Chinese population.
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Pathol, Beijing, Peoples R China;
通讯作者：
通讯机构：[3]Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pathol, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China;[4]Tsinghua Univ, Peking Union Med Coll, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Ao Ning,Wang Liang,Liu Yuqin.Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis[J].ONCOTARGETS AND THERAPY.2017,10:5533-5540.doi:10.2147/OTT.S139458.
APA：
Ao, Ning,Wang, Liang&Liu, Yuqin.(2017).Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis.ONCOTARGETS AND THERAPY,10,
MLA：
Ao, Ning,et al."Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis".ONCOTARGETS AND THERAPY 10.(2017):5533-5540
