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Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

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机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China; [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China; [5]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Key Lab Ophthalmol & Visual Sci, Beijing, Peoples R China; [6]Kailuan Hosp, Dept Cardiol, Tangshan, Peoples R China; [7]Capital Med Univ, Beijing Tongren Hosp, Key Lab Ophthalmol & Visual Sci, Beijing Inst Ophthalmol,Beijing Tongren Eye Ctr, Beijing, Peoples R China; [8]Ruprecht Karls Univ Heidelberg, Dept Ophthalmol, Med Fac Mannheim, Heidelberg, Germany

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Purpose To examine whether an abnormally thin retinal nerve fiber layer (RNFL) is associated with cerebrovascular insufficiency. Design Community-based study. Methods The Asymptomatic Polyvascular Abnormalities in Community Study included Chinese aged 40+ years and without histories of cerebrovascular incidents or coronary heart disease. Using transcranial Doppler and carotid duplex ultrasound examination, we assessed presence and degree of an intracranial arterial stenosis (ICAS) and extracranial carotid arterial stenosis (ECAS) and we measured the RNFL thickness by spectral-domain optical coherence tomography. Results The study included 3,376 participants with a mean age of 54.3 +/- 10.3 years. Thinner RNFL was significantly correlated with a higher prevalence of ECAS (P = 0.035; standardized regression coefficient beta:- 0.04; non- standardized regression coefficient B:- 0.99; 95% confidence intervals(CI):- 1.90,-0.07), after adjusting for age (P<0.001; beta:-0.25; B:-0.26; 95% CI:-0.30,-0.22), gender (P = 0.001; beta:-0.07; B:-1.36; 95% CI:-2.14,- 0.58) and blood concentration of low- density lipoproteins (P = 0.03; beta: 0.04; B: 0.52; 95% CI: 0.05,0.98). In a reverse manner, prevalence of ECAS was associated with a thinner RNFL thickness (P = 0.007; odds ratio (OR): 0.99; 95% CI: 0.98,0.99) after adjusting for older age (P<0.001; OR: 1.06; 95% CI: 10.05,10.7), higher prevalence of ICAS (P = 0.01; OR: 1.34; 95% CI: 1.07,1.69) and higher prevalence of carotid artery plaques (P<0.001; OR: 9.18; 95% CI: 6.93,12.2), and higher blood concentration of total cholesterol (P = 0.03; OR: 1.12; 95% CI: 1.01,1.23). In univariate analysis, an increasing degree of ECAS was significantly correlated with a thinner RNFL. Conclusions Higher prevalence and degree of ECAS were correlated with thinner RNFL and vice versa. Patients with abnormally thin RNFL without ocular disease may undergo carotid artery examination to detect asymptomatic carotid artery stenosis. Examination of the RNFL is useful for the diagnosis of cerebrovascular disease.

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出版当年[2016]版：

大类 | 3 区生物

小类 | 3 区综合性期刊

最新[2023]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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出版当年[2015]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 2.9 最新[2023版] 3.3 最新五年平均 3.057 出版当年[2015版] 3.535 出版当年五年平均 3.234 出版前一年[2014版] 2.806 出版后一年[2016版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China; [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China; [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China; [5]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Key Lab Ophthalmol & Visual Sci, Beijing, Peoples R China; [6]Kailuan Hosp, Dept Cardiol, Tangshan, Peoples R China;

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