Decreased Estimated Glomerular Filtration Rate (eGFR), Not Proteinuria, Is Associated with Asymptomatic Intracranial Arterial Stenosis in Chinese General Population
机构：[1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing, Peoples R China;[2]Capital Med Univ, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;国家神经系统疾病临床医学研究中心国家神经系统疾病临床医学研究中心首都医科大学附属天坛医院[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;[5]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing, Peoples R China;[6]Hebei United Univ, Kailuan Hosp, Dept Cardiol, Tangshan, Peoples R China
The relationship between chronic kidney disease (CKD), which is defined by declined estimated glomerular filtration rate (eGFR) and/or proteinuria, and asymptomatic intracranial arterial stenosis (ICAS) is largely unknown. We conducted a population-based, cross-sectional study by recruiting 5209 participants free of previous stroke, transient ischemic attack and coronary heart disease. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and proteinuria was estimated with urine dipstick. The presence of ICAS was assessed by transcranial color-coded Doppler (TCD). Out of the whole population, 684 (13.1%) participants suffered ICAS. After adjusting for the confounding factors, eGFR < 45 mI/min/m(2) was an independent risk factor of asymptomatic ICAS (odds ratio [OR], 3.29, 95% confidence interval [CI], 1.67-6.51), but the trend was different between the two groups stratified by the age of 60 (P = 0.01). However, the association between proteinuria and asymptomatic ICAS was not statistically significant. In conclusion, declined eGFR, not proteinuria, is associated with asymptomatic ICAS in Chinese general population, especially in people over 60 years old.
基金：
"DengFeng" personnel training program of Beijing Municipal Administration of Hospitals [DFL20150501]; [2014-2-010]
第一作者机构：[1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing, Peoples R China;[2]Capital Med Univ, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing, Peoples R China;[2]Capital Med Univ, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;[6]Hebei United Univ, Kailuan Hosp, Dept Cardiol, Tangshan, Peoples R China
推荐引用方式(GB/T 7714)：
Li Zhaoxia,Li Jinxin,Wang Anxin,et al.Decreased Estimated Glomerular Filtration Rate (eGFR), Not Proteinuria, Is Associated with Asymptomatic Intracranial Arterial Stenosis in Chinese General Population[J].SCIENTIFIC REPORTS.2017,7(1):-.doi:10.1038/s42598-017-04549-0.
APA：
Li, Zhaoxia,Li, Jinxin,Wang, Anxin,Pan, Hua,Wu, Shouling&Zhao, Xingquan.(2017).Decreased Estimated Glomerular Filtration Rate (eGFR), Not Proteinuria, Is Associated with Asymptomatic Intracranial Arterial Stenosis in Chinese General Population.SCIENTIFIC REPORTS,7,(1)
MLA：
Li, Zhaoxia,et al."Decreased Estimated Glomerular Filtration Rate (eGFR), Not Proteinuria, Is Associated with Asymptomatic Intracranial Arterial Stenosis in Chinese General Population".SCIENTIFIC REPORTS 7..1(2017):-
