机构：[1]China Ctr Dis Control & Prevent, WHO WPRO Reg Reference Measles Rubella Lab, Beijing, Peoples R China;[2]China Ctr Dis Control & Prevent, Key Lab Med Virol, Minist Hlth, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China;[3]Lu Juan Community Hlth Ctr Daxing Reg, Beijing, Peoples R China;[4]Childrens Hosp Changchun, Jilin Childrens Med Ctr, Changchun, Peoples R China;[5]Guangzhou Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China;[6]Hunan Prov Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China;[7]Shaanxi Prov Ctr Dis Control & Prevent, Xian, Peoples R China;[8]Capital Med Univ, Beijing Childrens Hosp, Beijing, Peoples R China;首都医科大学附属北京儿童医院[9]AbbVie Inc, N Chicago, IL USA;[10]Anhui Univ Sci & Technol, Med Coll, Huainan, Peoples R China
A molecular epidemiological study of human respiratory syncytial virus (HRSV) was conducted to examine the distribution of its subgroups and genotypes, as well as to identify its transmission pattern in China. A total of 705 samples collected from 9 provinces in China between January 2008 and February 2015 were identified as HRSV-positive and were subsequently sequenced. Of these, 336 samples were HRSV subgroup A (HRSVA), 368 samples were HRSV subgroup B (HRSVB), and 1 sample contained both HRSVA and HRSVB. These 705 HRSV sequences, together with 766 HRSV sequences downloaded from GenBank, were analyzed to understand the recent circulation patterns of HRSV in China. HRSVB predominated in the 2008/2009 and 2009/2010 seasons, whereas HRSVA predominated in the 2010/2011 and 2011/2012 seasons; HRSVA and HRSVB co-circulated during 2012/2013 and 2014/2015. Phylogenetic analysis showed most of the HRSVA sequences clustered into 2 genotypes, namely, NA1 and ON1. The ON1 genotype was first detected in China in 2011, and it quickly replaced the NA1 genotype to become the most prevalent HRSVA genotype circulating in China between 2013 and 2015. Continuous epidemiological surveillance and molecular characterization of HRSV should be conducted to monitor the evolution of HRSV in China.
基金：
Key Technologies R& D Program of National Ministry of Science and non-clinical laboratory service agreement [2013ZX10004202, 2012ZX10004201-003]; AbbVie Pharmaceutical Trading Co. Ltd
第一作者机构：[1]China Ctr Dis Control & Prevent, WHO WPRO Reg Reference Measles Rubella Lab, Beijing, Peoples R China;[2]China Ctr Dis Control & Prevent, Key Lab Med Virol, Minist Hlth, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]China Ctr Dis Control & Prevent, WHO WPRO Reg Reference Measles Rubella Lab, Beijing, Peoples R China;[2]China Ctr Dis Control & Prevent, Key Lab Med Virol, Minist Hlth, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China;[10]Anhui Univ Sci & Technol, Med Coll, Huainan, Peoples R China
推荐引用方式(GB/T 7714)：
Song Jinhua,Zhang Yan,Wang Huiling,et al.Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015[J].SCIENTIFIC REPORTS.2017,7(1):-.doi:10.1038/s41598-017-04824-0.
APA：
Song, Jinhua,Zhang, Yan,Wang, Huiling,Shi, Jing,Sun, Liwei...&Xu, Wenbo.(2017).Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015.SCIENTIFIC REPORTS,7,(1)
MLA：
Song, Jinhua,et al."Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015".SCIENTIFIC REPORTS 7..1(2017):-
