The C-reactive protein/albumin ratio (CAR) has been shown to play a significant prognostic role in several cancers. We aimed to comprehensively explore the potential role of the CAR as a prognostic indicator in solid cancers. In this meta-analysis, we collected data from 10 studies that examined the association between serum CAR and overall survival in patients with cancer. This meta-analysis included 4592 tumor patients. The eligible studies were found through the PubMed and Web of Science databases updated on 6 Oct 2016. The pooled hazard ratio (2.01, 95% CI: 1.58-2.56, p < 0.001) indicated that high CAR yielded worse survival in different cancers. Subgroup analyses showed a significant association between CAR and prognosis, regardless of the cutoff value, cutoff value selection, treatment method, country, sample size, stage and cancer type. This meta-analysis suggests that CAR may be a potential prognostic marker in solid cancers. However, further large prospective studies should be conducted to explore the critical role of CAR in survival of cancer patients.
基金：
Science and Technology Plan project in Shenyang City, China [F14-158-9-33]
第一作者机构：[1]China Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Shenyang 110001, Peoples R China;
通讯作者：
通讯机构：[1]China Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Shenyang 110001, Peoples R China;
推荐引用方式(GB/T 7714)：
Li Nan,Tian Guang-Wei,Wang Ying,et al.Prognostic Role of the Pretreatment C-Reactive Protein/Albumin Ratio in Solid Cancers: A Meta-Analysis[J].SCIENTIFIC REPORTS.2017,7:-.doi:10.1038/srep41298.
APA：
Li, Nan,Tian, Guang-Wei,Wang, Ying,Zhang, Hui,Wang, Zi-hui&Li, Guang.(2017).Prognostic Role of the Pretreatment C-Reactive Protein/Albumin Ratio in Solid Cancers: A Meta-Analysis.SCIENTIFIC REPORTS,7,
MLA：
Li, Nan,et al."Prognostic Role of the Pretreatment C-Reactive Protein/Albumin Ratio in Solid Cancers: A Meta-Analysis".SCIENTIFIC REPORTS 7.(2017):-
