机构：[1]The George Institute for Global Health, The University of Sydney, Sydney, New South Wales, Australia.[2]Neurology Department, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.[3]The University of Central Lancashire, Lancashire, UK.[4]Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.[5]Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.[6]Centre for Health Record Linkage, NSW Ministry of Health, Sydney, New South Wales, Australia.[7]Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.[8]Nuffield Department of Population Health, The George Institute for Global Health, Oxford University, Oxford, UK.[9]Department of Neurology, Peking University First Hospital, Beijing, China.[10]Department of Cardiovascular Sciences and NIHR Biomedical Research Unit for Cardiovascular Diseases, University of Leicester, Leicester, UK.[11]Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Universidad de Chile, Santiago, Chile.[12]Westmead Hospital Clinical School, Westmead, New South Wales, Australia.[13]Department of Neuroscience, CRCHUM, University of Montreal, Montreal, Quebec, Canada.[14]The George Institute for Global Health China at Peking University Health Sciences Center, Beijing, China.[15]Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2).
The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150-220 mm Hg). HRQoL was determined using the European Quality of Life Scale (EQ-5D) at 90 days, completed by patients or proxy responders. Binary logistic regression analyses were performed to identify factors associated with poor overall HRQoL.
2756 patients were included. Demographic, clinical and radiological factors associated with lower EQ-5D utility score were age, randomisation outside of China, antithrombotic use, high baseline National Institutes of Health Stroke Scale (NIHSS) score, larger ICH, presence of intraventricular extension and use of proxy responders. High (≥14) NIHSS score, larger ICH and proxy responders were associated with low scores in all five dimensions of the EQ-5D. The NIHSS score had a strong association with poor HRQoL (p<0.001). Female gender and antithrombotic use were associated with decreased scores in dimensions of pain/discomfort and usual activity, respectively.
Poor HRQoL was associated with age, comorbidities, proxy source of assessment, clinical severity and ICH characteristics. The strongest association was with initial clinical severity defined by high NIHSS score.
NCT00226096 and NCT00716079; Post-results.
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第一作者机构：[1]The George Institute for Global Health, The University of Sydney, Sydney, New South Wales, Australia.[2]Neurology Department, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
推荐引用方式(GB/T 7714)：
Delcourt Candice,Zheng Danni,Chen Xiaoying,et al.Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies.[J].JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY.2017,88(1):70-75.doi:10.1136/jnnp-2016-314414.
APA：
Delcourt Candice,Zheng Danni,Chen Xiaoying,Hackett Maree,Arima Hisatomi...&Sato Shoichiro.(2017).Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies..JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,88,(1)
MLA：
Delcourt Candice,et al."Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies.".JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 88..1(2017):70-75
医学