首都卫生发展科研专项项目(首发2011-1017-01)%北京市医院管理局临床医学发展专项-“扬帆”计划临床技术创新项目(XM-LX201514)%国家自然科学基金(81541109)%北京市卫生系统高层次卫生技术人才培养计划基金(2009-3-29)This research was supported by The capital health research and development of special(2011-1017-01)%Beijing Municipal Administra-tion of Hospitals Clinical medicine Development of special funding support(XMLX201514)%National Natural Science Foundation of China(81541109)%Beijing health system top level health technical personnel training plan(2009-3-29)