Difference of language cortex reorganization between cerebral arteriovenous malformations, cavernous malformations, and gliomas: a functional MRI study
The authors attempted to demonstrate the difference in language cortex reorganization between cerebral malformations (AVMs), cavernous malformations (CMs), and gliomas by blood oxygen level-dependent (BOLD) functional magnetic resonance imaging. Clinical and imaging data of 27 AVM patients (AVM-L group), 29 CM patients (CM-L group), and 20 glioma patients (Glioma-L group) were retrospectively reviewed, with lesions overlying the left inferior frontal gyrus (Broca area). As a control, patients with lesions involving the right inferior frontal gyrus were also enrolled, including 14 AVM patients (AVM-R group), 20 CM patients (CM-R group), and 14 glioma patients (Glioma-R group). All patients were right-handed. Lateralization indices (LI) of BOLD signal activations were calculated separately for Broca and Wernicke areas. In AVM-L group, right-sided lateralization of BOLD signals was observed in 10 patients (37.0 %), including 6 in the Broca area alone, 1 in the Wernicke area alone, and 3 in both areas. Three patients (10.3 %) of CM-L group showed right-sided lateralization in both Broca and Wernicke areas, and 1 patient (5.0 %) of Glioma-L group had right-sided lateralization in the Wernicke area alone. A significant difference of right-sided lateralization was observed between the AVM-L group and CM-L group (P = 0.018) and also between the AVM-L group and Glioma-L group (P = 0.027). No patient in AVM-R, CM-R, or Glioma-R groups showed right-sided lateralization. Language cortex reorganization may occur in AVM, CM, and glioma patients when the traditional language cortex was involved by lesions, but the potential of reorganization for CM and glioma patients seems to be insufficient compared with AVM patients.
基金：
Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2012CB825505, 2011BAI08B08]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2013BAI09B03]; Center of Stroke, Beijing Institute for Brain Disorders [BIBD-PXM2013_014226_07_000084]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis NCRC ND, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis NCRC ND, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Deng Xiaofeng,Xu Long,Zhang Yan,et al.Difference of language cortex reorganization between cerebral arteriovenous malformations, cavernous malformations, and gliomas: a functional MRI study[J].NEUROSURGICAL REVIEW.2016,39(2):241-249.doi:10.1007/s10143-015-0682-7.
APA：
Deng, Xiaofeng,Xu, Long,Zhang, Yan,Wang, Bo,Wang, Shuo...&Zhao, Jizong.(2016).Difference of language cortex reorganization between cerebral arteriovenous malformations, cavernous malformations, and gliomas: a functional MRI study.NEUROSURGICAL REVIEW,39,(2)
MLA：
Deng, Xiaofeng,et al."Difference of language cortex reorganization between cerebral arteriovenous malformations, cavernous malformations, and gliomas: a functional MRI study".NEUROSURGICAL REVIEW 39..2(2016):241-249
