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ULTRASOUND STRAIN ELASTOGRAPHY IN ASSESSMENT OF MUSCLE STIFFNESS IN ACUTE LEVODOPA CHALLENGE TEST: A FEASIBILITY STUDY

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收录情况: ◇ SCIE ◇ EI

机构: [1]Weill Cornell Med Coll, Dept Radiol, New York, NY USA; [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Ultrasound, 6 Tiantanxili, Beijing, Peoples R China
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关键词: Acute levodopa challenge test Muscle rigidity Parkinson's disease Speckle tracking Ultrasound strain elastography

摘要:
To evaluate the feasibility of ultrasound strain elastography in assessing the response of muscle stiffness to the acute levodopa test, we prospectively performed strain elastography on the biceps brachii muscle (BBM) of 18 patients to diagnose Parkinson's disease. BBM and subcutaneous tissue strains (deformations) were produced by external compression with an ultrasound transducer and estimated using 2-D speckle tracking. We used the strain ratio (SR 5 BBM strain/reference strain) to assess BBM stiffness. The rate of increase in SR [rate 5 (SR after levodopa-SR before levodopa)/SR before levodopa] was used to assess the muscle stiffness response to levodopa. SR significantly increased after levodopa administration in 11 patients with Parkinson's disease (p = 0.02), whereas it did not in 7 patients with parkinsonian syndrome (from non-Parkinson's causes) (p = 0.14). The area under the receiver operating characteristic curve for the rate of increase in SR in determining Parkinson's disease was 0.96. The rate of increase in SR seems to be feasible in evaluating the effect of levodopa on muscle stiffness in the diagnosis of Parkinson's disease. (C) 2016 World Federation for Ultrasound in Medicine & Biology.

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出版当年[2015]版:
大类 | 3 区 医学
小类 | 2 区 声学 3 区 核医学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 声学 3 区 核医学
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出版当年[2014]版:
Q1 ACOUSTICS Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 ACOUSTICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Weill Cornell Med Coll, Dept Radiol, New York, NY USA;
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通讯机构: [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Ultrasound, 6 Tiantanxili, Beijing, Peoples R China
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