机构:[1]Weill Cornell Med Coll, Dept Radiol, New York, NY USA;[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Ultrasound, 6 Tiantanxili, Beijing, Peoples R China医技科室超声科首都医科大学附属天坛医院
To evaluate the feasibility of ultrasound strain elastography in assessing the response of muscle stiffness to the acute levodopa test, we prospectively performed strain elastography on the biceps brachii muscle (BBM) of 18 patients to diagnose Parkinson's disease. BBM and subcutaneous tissue strains (deformations) were produced by external compression with an ultrasound transducer and estimated using 2-D speckle tracking. We used the strain ratio (SR 5 BBM strain/reference strain) to assess BBM stiffness. The rate of increase in SR [rate 5 (SR after levodopa-SR before levodopa)/SR before levodopa] was used to assess the muscle stiffness response to levodopa. SR significantly increased after levodopa administration in 11 patients with Parkinson's disease (p = 0.02), whereas it did not in 7 patients with parkinsonian syndrome (from non-Parkinson's causes) (p = 0.14). The area under the receiver operating characteristic curve for the rate of increase in SR in determining Parkinson's disease was 0.96. The rate of increase in SR seems to be feasible in evaluating the effect of levodopa on muscle stiffness in the diagnosis of Parkinson's disease. (C) 2016 World Federation for Ultrasound in Medicine & Biology.
基金:
Capital Research Grant for Clinical Application (China) [Z121107001012140]
语种:
外文
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2015]版:
大类|3 区医学
小类|2 区声学3 区核医学
最新[2023]版:
大类|3 区医学
小类|3 区声学3 区核医学
JCR分区:
出版当年[2014]版:
Q1ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2ACOUSTICS
第一作者机构:[1]Weill Cornell Med Coll, Dept Radiol, New York, NY USA;
通讯作者:
通讯机构:[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Ultrasound, 6 Tiantanxili, Beijing, Peoples R China
推荐引用方式(GB/T 7714):
Gao Jing,Du Li-Juan,He Wen,et al.ULTRASOUND STRAIN ELASTOGRAPHY IN ASSESSMENT OF MUSCLE STIFFNESS IN ACUTE LEVODOPA CHALLENGE TEST: A FEASIBILITY STUDY[J].ULTRASOUND IN MEDICINE AND BIOLOGY.2016,42(5):1084-1089.doi:10.1016/j.ultrasmedbio.2015.12.014.
APA:
Gao, Jing,Du, Li-Juan,He, Wen,Li, Shuo&Cheng, Ling-Gang.(2016).ULTRASOUND STRAIN ELASTOGRAPHY IN ASSESSMENT OF MUSCLE STIFFNESS IN ACUTE LEVODOPA CHALLENGE TEST: A FEASIBILITY STUDY.ULTRASOUND IN MEDICINE AND BIOLOGY,42,(5)
MLA:
Gao, Jing,et al."ULTRASOUND STRAIN ELASTOGRAPHY IN ASSESSMENT OF MUSCLE STIFFNESS IN ACUTE LEVODOPA CHALLENGE TEST: A FEASIBILITY STUDY".ULTRASOUND IN MEDICINE AND BIOLOGY 42..5(2016):1084-1089