The World Health Organization (WHO) grading of gliomas stratifies tumors by histology. However, the aggressiveness of tumors in each grade still shows great heterogeneity. Phosphohistone H3 (pHH3) has been reported as an accurate marker of cells within the mitotic phase of the cell cycle in many kinds of cancers. To evaluate the role of pHH3 in predicting patient outcome and to annotate the functions of pHH3 in WHO grade II-IV gliomas, we analyzed the expression pattern of pHH3 and pHH3 associated genes by IHC and mRNA expression profiling. Phosphohistone H3, mRNA enrichment of histone H3 and associated gene signature all showed prognostic value in adult diffuse gliomas. Gene set enrichment analysis suggested that the expression of pHH3 had positive correlation with both epithelial to mesenchymal transition and immune response. These findings suggest that subgroups of diffuse gliomas defined by pHH3 and pHH3 signatures possess distinctive prognostic and biological characteristics.
基金：
Research Special Fund for Public Welfare Industry of Heath [201402008]; National High Technology Research and Development ProgramNational High Technology Research and Development Program of China [2012AA02A508]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [91229121, 8150110349, 81502606]; Beijing Science and Technology Plan [Z131100006113018]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2013BA109B03, 2014BA104B02]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20121107120005]; Fok Ying Tung Education FoundationFok Ying Tung Education Foundation [141032]; Beijing Nova ProgramBeijing Municipal Science & Technology Commission [xx2014B062]
第一作者机构：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Otolaryngol, Wuhan 430022, Peoples R China;
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Otolaryngol, Wuhan 430022, Peoples R China;[2]Capital Med Univ, Beijing Neurosurg Inst, Dept Mol Neuropathol, Beijing 100050, Peoples R China;[3]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;[4]Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing 100069, Peoples R China;[5]China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Zhu Ping,Zhang Chuan-Bao,Yang Pei,et al.Phosphohistone H3 (pHH3) is a prognostic and epithelial to mesenchymal transition marker in diffuse gliomas[J].ONCOTARGET.2016,7(29):45005-45014.doi:10.18632/oncotarget.7154.
APA：
Zhu, Ping,Zhang, Chuan-Bao,Yang, Pei,Chen, Jing,Liu, Yu-Qing...&Jiang, Tao.(2016).Phosphohistone H3 (pHH3) is a prognostic and epithelial to mesenchymal transition marker in diffuse gliomas.ONCOTARGET,7,(29)
MLA：
Zhu, Ping,et al."Phosphohistone H3 (pHH3) is a prognostic and epithelial to mesenchymal transition marker in diffuse gliomas".ONCOTARGET 7..29(2016):45005-45014
医学