The study was aim to assess the impact of biochanin A on the oral bioavailability and pharmacokinetics (PK) of saquinavir (SQV), a substrate of P-glycoprotein (P-gp), in rats. 10 male rats were randomized into 2 groups of equal size, and administered orally 30 mg/kg SQV with or without 20 mg/kg biochanin A. The PK of SQV was assessed using non-compartmental analysis. Results revealed that the area under the plasma concentration-time curve of SQV from time zero to time infinity (AUC(0-infinity)) was reduced by 51.39 % by biochanin A (P = 0.038); while the apparent systemic clearance (CL/F) was increased by 87.62 % (P = 0.028). Double peak phenomenon was observed in the plasma SQV profiles. Biochanin A increased the first peak, yet decreased the second peak of plasma SQV levels. Our study demonstrates that biochanin A can significantly reduce SQV oral bioavailability and alter SQV PK profiles in rats. Findings in this study suggest a precaution in the clinic when SQV is administered with dietary/herbal supplements that contain biochanin A.
基金：
Grant of the National Natural Science Foundation of China [81102877]
语种：
外文
被引次数：
WOS：
PubmedID：
第一作者：
第一作者机构：[1]Peking Univ, Peoples Hosp, Dept Pharm, 11 Xizhimen South St, Beijing 100044, Peoples R China;[2]Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Peking Univ, Peoples Hosp, Dept Pharm, 11 Xizhimen South St, Beijing 100044, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Dept Pharm, 56 Nanlishi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Li J.,Liu Y.,Yu X.,et al.Reduced Oral Bioavailability and Altered Pharmacokinetics of Saquinavir by Co-administration with Biochanin A in Rats[J].DRUG RESEARCH.2016,66(9):484-488.doi:10.1055/s-0042-110393.
APA：
Li, J.,Liu, Y.,Yu, X.,Zhang, J.,Gu, J.&Zhao, L..(2016).Reduced Oral Bioavailability and Altered Pharmacokinetics of Saquinavir by Co-administration with Biochanin A in Rats.DRUG RESEARCH,66,(9)
MLA：
Li, J.,et al."Reduced Oral Bioavailability and Altered Pharmacokinetics of Saquinavir by Co-administration with Biochanin A in Rats".DRUG RESEARCH 66..9(2016):484-488
