机构：[1]Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China;[2]Univ Chinese Acad Sci, Beijing, Peoples R China;[3]Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China;[4]Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Beijing, Peoples R China;[5]Capital Med Univ, Beijing Childrens Hosp, Ctr Med Genet, Beijing, Peoples R China;临床科室内分泌科首都医科大学附属北京儿童医院[6]Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China;[7]MOE Key Lab Major Dis Children, Beijing, Peoples R China;[8]Beijing Pediat Res Inst, Beijing, Peoples R China
Notch signaling plays a crucial role in controling the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis, but its regulation is incompletely understood. BLOS2, encoded by the Bloc1s2 gene, is a shared subunit of two lysosomal trafficking complexes, biogenesis of lysosome-related organelles complex-1 (BLOC-1) and BLOC-1-related complex (BORC). Bloc1s2(-/-) mice were embryonic lethal and exhibited defects in cortical development and hematopoiesis. Loss of BLOS2 resulted in elevated Notch signaling, which consequently increased the proliferation of neural progenitor cells and inhibited neuronal differentiation in cortices. Likewise, ablation of bloc1s2 in zebrafish or mice led to increased hematopoietic stem and progenitor cell production in the aorta-gonad-mesonephros region. BLOS2 physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. Our findings suggest that BLOS2 is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [91539204, 31471333, 31271570, 31230046, 91332116, 31425016]; Chinese Academy of SciencesChinese Academy of Sciences [KJZD-EW-L08, XDA01010110]; Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2010CB945300, 2011CB943900]
第一作者机构：[1]Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China;[2]Univ Chinese Acad Sci, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China;[2]Univ Chinese Acad Sci, Beijing, Peoples R China;[3]Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China;[5]Capital Med Univ, Beijing Childrens Hosp, Ctr Med Genet, Beijing, Peoples R China;[6]Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China;[7]MOE Key Lab Major Dis Children, Beijing, Peoples R China;[8]Beijing Pediat Res Inst, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Zhou Wenwen,He Qiuping,Zhang Chunxia,et al.BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development[J].ELIFE.2016,5(OCTOBER2016):-.doi:10.7554/eLife.18108.
APA：
Zhou, Wenwen,He, Qiuping,Zhang, Chunxia,He, Xin,Cui, Zongbin...&Li, Wei.(2016).BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.ELIFE,5,(OCTOBER2016)
MLA：
Zhou, Wenwen,et al."BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development".ELIFE 5..OCTOBER2016(2016):-
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