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Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B

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收录情况： ◇ SCIE

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机构： [1]Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China; [2]Beijing Key Lab Translat Med Liver Cirrhosis, Beijing 100050, Peoples R China; [3]Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China; [4]Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China; [5]Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China; [6]Xinjiang Med Univ, Affiliated Hosp 1, Urumqi 830054, Peoples R China; [7]Jilin Univ, Hosp 1, Changchun 130021, Peoples R China; [8]Tianjin Med Univ, Tianjin Cent Hosp 3, Tianjin 300170, Peoples R China; [9]China Med Univ, Shengjing Hosp, Shenyang 110022, Peoples R China; [10]Henan Prov Peoples Hosp, Zhengzhou 450003, Peoples R China; [11]Sichuan Univ, West China Hosp, Chengdu 610041, Peoples R China; [12]Jiao Tong Univ, Sch Med, Shanghai Ruijin Hosp, Shanghai 200025, Peoples R China; [13]Capital Med Univ, Beijing Youan Hosp, Beijing 100069, Peoples R China; [14]Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [15]Peking Univ, Hosp 1, Beijing 100034, Peoples R China; [16]Capital Med Univ, Beijing Ditan Hosp, Beijing 100015, Peoples R China; [17]Peking Union Med Coll Hosp, Beijing 100730, Peoples R China; [18]Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China; [19]Third Peoples Hosp Taiyuan, Taiyuan 030012, Peoples R China; [20]Peking Univ, Hlth Sci Ctr, Beijing 100191, Peoples R China; [21]Duke Univ, Sch Med, Dept Biostat & Bioinformat, Durham, NC 27710 USA

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摘要：

Female gender and younger age are protective factors against disease progression in chronic hepatitis B (CHB). However, it is not clear whether the disease progression still remains slow in elderly females. This study investigated the interaction of female gender and older age on the development of cirrhosis in patients recorded in China Registry of Hepatitis B. A total of 17,809 CHB patients were enrolled in this multi-center cross-sectional study. The prevalence of cirrhosis in female CHB patients increased faster than that in male CHB patients over 50 years old. Multivariate analysis showed that the increase of adjusted ORs for developing cirrhosis in females started to accelerate after 50 years old: 11.19 (95% CI: 5.93-21.11) in women versus 14.75 (95% CI: 8.35-26.07) in men at ages of 50-59 years, 21.67 (95% CI: 11.05-42.47) versus 24.4 (95% CI: 13.00-45.80) at ages 60-69 years, and 18.78 (95% CI: 6.61-53.36) versus 12.09 (95% CI: 4.35-33.61) in those over 70 years. In conclusion, the protective effect of female gender against cirrhosis gradually lost with increasing age, therefore disease progression should be monitored more closely in elderly women with CHB.

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出版当年[2015]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

最新[2023]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

JCR分区：

出版当年[2014]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.8 最新[2023版] 4.3 最新五年平均 5.578 出版当年[2014版] 5.597 出版当年五年平均 5.078 出版前一年[2013版] 5.228 出版后一年[2015版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China; [2]Beijing Key Lab Translat Med Liver Cirrhosis, Beijing 100050, Peoples R China; [3]Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China; [2]Beijing Key Lab Translat Med Liver Cirrhosis, Beijing 100050, Peoples R China; [3]Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China;

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