Background and aims: Given the recognized links between atherosclerosis and cognitive impairment, the aim of this study was to examine the association between the ankle-brachial index (ABI) and cognitive impairment in a cross-sectional setting of a Chinese population. Methods: Participants (n = 3,048, aged >= 40 years, 1727 men and 1321 women) were recruited from the ongoing community-based Asymptomatic Polyvascular Abnormalities Community Study. ABI was measured and a low ABI was defined as <0.9. Cognition status was evaluated via the Mini-Mental Status Exam. Multivariate logistic regression models and linear regression models were used to assess the association between ABI and cognitive impairment. Results: A low ABI was associated with cognitive impairment (odds ratio, OR = 1.983; 95% confidence interval, CI: 1.150-3.419), independent of the potential confounders. In addition, a decreasing ABI (per standard deviation) was significantly associated with cognitive impairment in fully adjusted models (OR = 1.156; CI: 1.013-1.319) and with a significant trend of decreasing MMSE scores (beta = 0.703, 95% CI 0.189-1.218, p = 0.0074). Furthermore, the odds of a low ABI associated with cognitive impairment in participants without hypertension and participants with diabetes were 4.924 (CI: 1.860-13.035) and 6.393 (CI: 2.431-16.810), respectively. Conclusions: A low ABI is associated with cognitive impairment, especially in non-hypertensive and diabetic patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
基金：
"Beijing Health System Medical High Level Academic Leader Plan" [2014-2-010]; "Beijing Municipal Administration of Hospitals' Apex Plan" [DFL20150501]; "Beijing Municipal Science & Technology Commission''Beijing Municipal Science & Technology Commission [Z161100002616008]
第一作者机构：[1]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, 6 Tiantanxili, Beijing 100050, Peoples R China;[3]China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China;[4]Beijing Inst Brain Disorders, Ctr Stroke, Beijing 100050, Peoples R China;[5]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[2]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, 6 Tiantanxili, Beijing 100050, Peoples R China;[3]China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China;[4]Beijing Inst Brain Disorders, Ctr Stroke, Beijing 100050, Peoples R China;[5]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing 100050, Peoples R China;
推荐引用方式(GB/T 7714)：
Wang Anxin,Jiang Ruixuan,Su Zhaoping,et al.A low ankle-brachial index is associated with cognitive impairment: The APAC study[J].ATHEROSCLEROSIS.2016,255:90-95.doi:10.1016/j.atherosclerosis.2016.11.005.
APA：
Wang, Anxin,Jiang, Ruixuan,Su, Zhaoping,Jia, Jiaokun,Zhang, Ning...&Zhao, Xingquan.(2016).A low ankle-brachial index is associated with cognitive impairment: The APAC study.ATHEROSCLEROSIS,255,
MLA：
Wang, Anxin,et al."A low ankle-brachial index is associated with cognitive impairment: The APAC study".ATHEROSCLEROSIS 255.(2016):90-95
