To investigate the therapeutic effect of minimally invasive interventional treatment of brain hematoma, 128 patients with brain hematoma were randomly divided into two groups, including observation group (64 cases) and control group (64 cases). The observation group was performed with minimally invasive interventional therapy and drug conservative therapy was used in the control group. Clinical curative effect, treatment of neural function defect score, and quality of life score were recorded. Total effective rate in observation group was significantly higher (p<0.05) than that in control group (90.6% vs 62.5%). And the mortality in observation group was significantly lower (p<0.05) than that in control group (3.1% vs 9.4%). National Institute of Health stroke scale (NIHSS) and Quality of Life (QOL) of the two groups after treatment were improved significantly (p<0.05) compared with those with treatment before; and the improved level of concept in observation group was significantly higher (p<0.05) than that of control group. Therefore, minimally invasive interventional brain hematoma surgery can effectively remove the hematoma in the brain, improve the nerve function of patients caused by trauma and improve the quality of life.