机构:[1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China;[2]Peking Union Med Coll, Beijing 100730, Peoples R China;[3]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China;重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[4]Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China;[5]Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China;[6]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China;[7]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
Chronic exposure to elevated levels of glucocorticoids can exert a neurotoxic effect in patients, possibly manifesting as molecular imaging alterations in patients. The aim of this study was to investigate the potential association between brain metabolism and elevated hormone level using F-18-fluorodeoxyglucose positron emission tomography. We retrospectively enrolled 92 consecutive patients with confirmed diagnosis of Cushing's disease. A voxel-based analysis was performed to investigate the association between cerebral F-18-fluorodeoxyglucose uptake and serum cortisol level. Relatively impaired metabolism of specific brain regions correlated with serum-cortisol level was found. Specifically, notable correlations were found in the hippocampus, amygdala, and cerebellum, regions considered to be involved in the regulation and central action of glucocorticoids. Moreover, some hormone-associated regions were found in the frontal and occipital cortex, possibly mediating the cognitive changes seen in Cushing's disease. Our findings link patterns of perturbed brain metabolism relates to individual hormone level, thus presenting a substrate for cognitive disturbances seen in Cushing's disease patients, as well as in other conditions with abnormal cortisol levels. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81201121]
第一作者机构:[1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China;[2]Peking Union Med Coll, Beijing 100730, Peoples R China;
通讯作者:
通讯机构:[2]Peking Union Med Coll, Beijing 100730, Peoples R China;[7]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714):
Liu Shuai,Wang Yinyan,Xu Kaibin,et al.Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET[J].NEUROIMAGE-CLINICAL.2016,12:415-419.doi:10.1016/j.nicl.2016.08.018.
APA:
Liu, Shuai,Wang, Yinyan,Xu, Kaibin,Ping, Fan,Wang, Renzhi...&Cheng, Xin.(2016).Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET.NEUROIMAGE-CLINICAL,12,
MLA:
Liu, Shuai,et al."Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET".NEUROIMAGE-CLINICAL 12.(2016):415-419