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Phylogenetic evidence for intratypic recombinant events in a novel human adenovirus C that causes severe acute respiratory infection in children

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机构: [1]Minist Hlth, Key Lab Med Virol, Beijing 102206, Peoples R China; [2]China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China; [3]Capital Med Univ, Beijing Pediat Res Inst, Beijing Childrens Hosp, Key Lab Major Dis Children,Minist Educ, Beijing 100045, Peoples R China; [4]Capital Med Univ, Beijing Pediat Res Inst, Beijing Childrens Hosp, Natl Key Discipline Pediat,Minist Educ, Beijing 100045, Peoples R China; [5]Fudan Univ, Children Hosp, Shanghai 200032, Peoples R China
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Human adenoviruses (HAdVs) are prevalent in hospitalized children with severe acute respiratory infection (SARI). Here, we report a unique recombinant HAdV strain (CBJ113) isolated from a HAdV-positive child with SARI. The whole-genome sequence was determined using Sanger sequencing and high-throughput sequencing. A phylogenetic analysis of the complete genome indicated that the CBJ113 strain shares a common origin with HAdV-C2, HAdV-C6, HAdV-C1, HAdV-C5, and HAdV-C57 and formed a novel subclade on the same branch as other HAdV-C subtypes. BootScan and single nucleotide polymorphism analyses showed that the CBJ113 genome has an intra-subtype recombinant structure and comprises gene regions mainly originating from two circulating viral strains: HAdV-1 and HAdV-2. The parental penton base, pVI, and DBP genes of the recombinant strain clustered with the HAdV-1 prototype strain, and the E1B, hexon, fiber, and 100 K genes of the recombinant clustered within the HAdV-2 subtype, meanwhile the E4orf1 and DNA polymerase genes of the recombinant shared the greatest similarity with those of HAdV-5 and HAdV-6, respectively. All of these findings provide insight into our understanding of the dynamics of the complexity of the HAdV-C epidemic. More extensive studies should address the pathogenicity and clinical characteristics of the novel recombinant.

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出版当年[2015]版:
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
最新[2023]版:
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
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出版当年[2014]版:
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版:
Q1 MULTIDISCIPLINARY SCIENCES

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第一作者:
第一作者机构: [1]Minist Hlth, Key Lab Med Virol, Beijing 102206, Peoples R China; [2]China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China;
通讯作者:
通讯机构: [1]Minist Hlth, Key Lab Med Virol, Beijing 102206, Peoples R China; [2]China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China;
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