Objective: To investigate whether abnormal glucose regulation contributes to a new stroke in patients with a minor ischemic stroke or TIA. Methods: We derived data from the Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events trial. Patients with a minor stroke or TIA were categorized into 3 groups: patients with diabetes mellitus (DM), impaired fasting glucose (IFG), and normal fasting plasma glucose. The primary outcome was a new stroke (ischemic or hemorrhagic) at 90 days. We assessed the association between glucose regulation status and risk of stroke by multivariable Cox regression models adjusted for potential covariates. Results: Among 5,135 included patients, 1,587 (30.9%), 409 (8.0%), and 3,139 (61.1%) patients were identified as DM, IFG, and normal glucose, respectively. Compared with normal glucose, IFG (11.0% vs 6.9%; adjusted hazard ratio [adj HR] 1.57, 95% confidence interval [CI] 1.13-2.19) and DM (15.8% vs 6.9%; adj HR 2.38, 95% CI 1.97-2.88) were associated with increased risk of stroke at 3 months after a minor stroke or TIA after adjusted for potential covariates. We found a weak J-shaped association between fasting plasma glucose and risk of stroke with a nadir of 4.9 mmol/L. Conclusions: Both IFG and DM were associated with an increased risk of stroke in patients with a minor stroke or TIA.
基金:
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2006BAI01A11, 2011BAI08B01, 2011BAI08B02, 2012ZX09303-005-001, 2013BAI09B03, 2015BAI09B01]; Beijing Biobank of Cerebral Vascular Disease [D131100005313003]; Beijing Institute for Brain Disorders [BIBD-PXM2013_014226_07_000084]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81322019]
第一作者机构:[1]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China;
通讯作者:
通讯机构:[1]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China;[4]Beijing Inst Brain Disorders, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[5]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[6]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China
推荐引用方式(GB/T 7714):
Pan Yuesong,Jing Jing,Li Hao,et al.Abnormal glucose regulation increases stroke risk in minor ischemic stroke or TIA[J].NEUROLOGY.2016,87(15):1551-1556.doi:10.1212/WNL.0000000000003200.
APA:
Pan, Yuesong,Jing, Jing,Li, Hao,Wang, Yongjun,Wang, Yilong&He, Yan.(2016).Abnormal glucose regulation increases stroke risk in minor ischemic stroke or TIA.NEUROLOGY,87,(15)
MLA:
Pan, Yuesong,et al."Abnormal glucose regulation increases stroke risk in minor ischemic stroke or TIA".NEUROLOGY 87..15(2016):1551-1556