当前位置: 首页 > 详情页

Abnormal glucose regulation increases stroke risk in minor ischemic stroke or TIA

文献详情

资源类型:

收录情况: ◇ SCIE

机构: [1]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China; [4]Beijing Inst Brain Disorders, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [5]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China; [6]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China
出处:
ISSN:

摘要:
Objective: To investigate whether abnormal glucose regulation contributes to a new stroke in patients with a minor ischemic stroke or TIA. Methods: We derived data from the Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events trial. Patients with a minor stroke or TIA were categorized into 3 groups: patients with diabetes mellitus (DM), impaired fasting glucose (IFG), and normal fasting plasma glucose. The primary outcome was a new stroke (ischemic or hemorrhagic) at 90 days. We assessed the association between glucose regulation status and risk of stroke by multivariable Cox regression models adjusted for potential covariates. Results: Among 5,135 included patients, 1,587 (30.9%), 409 (8.0%), and 3,139 (61.1%) patients were identified as DM, IFG, and normal glucose, respectively. Compared with normal glucose, IFG (11.0% vs 6.9%; adjusted hazard ratio [adj HR] 1.57, 95% confidence interval [CI] 1.13-2.19) and DM (15.8% vs 6.9%; adj HR 2.38, 95% CI 1.97-2.88) were associated with increased risk of stroke at 3 months after a minor stroke or TIA after adjusted for potential covariates. We found a weak J-shaped association between fasting plasma glucose and risk of stroke with a nadir of 4.9 mmol/L. Conclusions: Both IFG and DM were associated with an increased risk of stroke in patients with a minor stroke or TIA.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2015]版:
大类 | 1 区 医学
小类 | 1 区 临床神经病学
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 临床神经病学
JCR分区:
出版当年[2014]版:
Q1 CLINICAL NEUROLOGY
最新[2023]版:
Q1 CLINICAL NEUROLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者:
第一作者机构: [1]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [3]Beijing Inst Brain Disorders, Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China; [4]Beijing Inst Brain Disorders, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [5]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China; [6]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:16409 今日访问量:0 总访问量:869 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持:重庆聚合科技有限公司 地址:北京市西城区长椿街45号宣武医院